Diseases

Central Pontine Myelinolysis

A demyelinating condition affecting the PONS and characterized clinically by an acute progressive QUADRIPLEGIA; DYSARTHRIA; DYSPHAGIA; and alterations of consciousness. Pathologic features include prominent demyelination in the central PONS with sparing of axons and neurons. This condition is usually associated with systemic disorders such as HYPONATREMIA; chronic ALCOHOLISM; LIVER FAILURE; severe BURNS; malignant NEOPLASMS; hemorrhagic PANCREATITIS; HEMODIALYSIS; and SEPSIS. The rapid medical correction of hyponatremia has been cited as a cause of this condition. (From Adams et al., Principles of Neurology, 6th ed, pp1125-6)

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A demyelinating condition affecting the PONS and characterized clinically by an acute progressive QUADRIPLEGIA; DYSARTHRIA; DYSPHAGIA; and alterations of consciousness. Pathologic features include prominent demyelination in the central PONS with sparing of axons and neurons. This condition is usually associated with systemic disorders such as HYPONATREMIA; chronic ALCOHOLISM; LIVER FAILURE; severe BURNS; malignant NEOPLASMS; hemorrhagic PANCREATITIS; HEMODIALYSIS; and SEPSIS. The rapid medical correction of hyponatremia has been cited as a cause of this condition. (From Adams et al., Principles of Neurology, 6th ed, pp1125-6)

MeSH Record

Classification

Broader headings

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MeSH Record

Synonyms

12 entry terms
  • Myelinoclasis, Central Pontine
  • Myelinolysis, Central Pontine
  • Pontine Myelinolysis, Central
  • Central Pontine Myelinoclasis
  • Extrapontine Myelinoclasis
  • Extrapontine Myelinolysis
  • Extrapontine Myelinoclases
  • Extrapontine Myelinolyses
  • Myelinoclases, Extrapontine
  • Myelinoclasis, Extrapontine
  • Myelinolyses, Extrapontine
  • Myelinolysis, Extrapontine

MeSH Record

Aspects Covered

35 allowable subheadings

Indexed with the subheadings blood, cerebrospinal fluid, chemically induced, classification, complications, congenital, diagnosis, diagnostic imaging, diet therapy, drug therapy, economics, embryology, enzymology, epidemiology, ethnology, etiology, genetics, history, immunology, metabolism, microbiology, mortality, nursing, parasitology, pathology, physiopathology, prevention & control, psychology, radiotherapy, rehabilitation, surgery, therapy, urine, veterinary, virology.

MeSH Record

History Note

1994

MeSH Record

Previous Indexing

  • Demyelinating Diseases (1966-1993)
  • Pons (1966-1993)

MeSH Hierarchy

Tree Numbers

  1. C10w.228w.140w.163.560w
  2. C10w.314w.500w
  3. C18.452w.132.560w

AMA Style

References

  1. National Library of Medicine. Central Pontine Myelinolysis. Medical Subject Headings (MeSH). 2026. Unique ID D017590. http://id.nlm.nih.gov/mesh/2026/D017590
  2. Central Pontine Myelinolysis. In: Wikipedia. https://en.wikipedia.org/wiki/Central_pontine_myelinolysis
  3. Central Pontine Myelinolysis. In: Wikidata. https://www.wikidata.org/wiki/Q190370