Chemicals and Drugs

Ceruletide

A specific decapeptide obtained from the skin of Hila caerulea, an Australian amphibian. Caerulein is similar in action and composition to CHOLECYSTOKININ. It stimulates gastric, biliary, and pancreatic secretion; and certain smooth muscle. It is used in paralytic ileus and as diagnostic aid in pancreatic malfunction.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A specific decapeptide obtained from the skin of Hila caerulea, an Australian amphibian. Caerulein is similar in action and composition to CHOLECYSTOKININ. It stimulates gastric, biliary, and pancreatic secretion; and certain smooth muscle. It is used in paralytic ileus and as diagnostic aid in pancreatic malfunction.

Chemical Identity

Chemical Information

Molecular Formula
C58H73N13O21S2
Molecular Weight
1352.4 g/mol
CAS Registry No.
17650-98-5
IUPAC Name
(3S)-3-[[(2S)-5-amino-5-oxo-2-[[(2S)-5-oxopyrrolidine-2-carbonyl]amino]pentanoyl]amino]-4-[[(2S)-1-[[(2S,3R)-1-[[2-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-amino-1-oxo-3-phenylpropan-2-yl]amino]-3-carboxy-1-oxopropan-2-yl]amino]-4-methylsulfanyl-1-oxobutan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-2-oxoethyl]amino]-3-hydroxy-1-oxobutan-2-yl]amino]-1-oxo-3-(4-sulfooxyphenyl)propan-2-yl]amino]-4-oxobutanoic acid
InChIKey
YRALAIOMGQZKOW-HYAOXDFASA-N
SMILES
C[C@H]([C@@H](C(=O)NCC(=O)N[C@@H](CC1=CNC2=CC=CC=C21)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CC3=CC=CC=C3)C(=O)N)NC(=O)[C@H](CC4=CC=C(C=C4)OS(=O)(=O)O)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCC(=O)N)NC(=O)[C@@H]5CCC(=O)N5)O
MeSH Unique ID
D002108
Source
PubChem CID 16129675

MeSH Record

Classification

Broader headings

Related Concepts

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MeSH Record

Synonyms

7 entry terms
  • Caerulein
  • Cerulein
  • Ceruletid
  • FI-6934
  • Takus
  • FI 6934
  • FI6934

MeSH Record

Aspects Covered

30 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analogs & derivatives, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.

MeSH Record

Indexing Annotation

do not confuse entry term CERULEIN with CERULENIN

MeSH Record

History Note

2013(1972)

MeSH Record

Previous Indexing

  • Gastrointestinal Agents (1967-1971)
  • Peptides (1966-1971)

MeSH Hierarchy

Tree Number

  1. D12.644w.456w.241w

AMA Style

References

  1. National Library of Medicine. Ceruletide. Medical Subject Headings (MeSH). 2026. Unique ID D002108. http://id.nlm.nih.gov/mesh/2026/D002108
  2. Ceruletide. In: Wikipedia. https://en.wikipedia.org/wiki/Ceruletide
  3. Ceruletide. In: Wikidata. https://www.wikidata.org/wiki/Q5065299
  4. Ceruletide. In: PubChem Compound. CID 16129675. https://pubchem.ncbi.nlm.nih.gov/compound/16129675