Phenomena and Processes

Chaperone-Mediated Autophagy

A selective type of autophagy in which a specific set of cytosolic proteins are moved across the membrane of the LYSOSOMES by protein translocation, rather than by invagination of the lysosomal membrane. The proteins that will be degraded by chaperone-mediated autophagy (CMA) contain a CMA-targeting motif that, when exposed, is recognized by the cytosolic chaperone HSPA8 (aka Hsc70) and cochaperones which deliver the protein to LAMP2A monomers on the lysosome cell surface for translocation via the LAMP2A translocation complex. CMA is distinguished from CHAPERONE-ASSISTED-SELECTIVE AUTOPHAGY - a type of selective MACROAUTOPHAGY.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A selective type of autophagy in which a specific set of cytosolic proteins are moved across the membrane of the LYSOSOMES by protein translocation, rather than by invagination of the lysosomal membrane. The proteins that will be degraded by chaperone-mediated autophagy (CMA) contain a CMA-targeting motif that, when exposed, is recognized by the cytosolic chaperone HSPA8 (aka Hsc70) and cochaperones which deliver the protein to LAMP2A monomers on the lysosome cell surface for translocation via the LAMP2A translocation complex. CMA is distinguished from CHAPERONE-ASSISTED-SELECTIVE AUTOPHAGY - a type of selective MACROAUTOPHAGY.

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Classification

Broader headings

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MeSH Record

Synonyms

2 entry terms
  • Autophagy, Chaperone-Mediated
  • Chaperone Mediated Autophagy

MeSH Record

Aspects Covered

5 allowable subheadings

Indexed with the subheadings drug effects, genetics, immunology, physiology, radiation effects.

MeSH Record

History Note

2020

MeSH Record

Previous Indexing

  • Autophagy (2000-2019)

MeSH Hierarchy

Tree Number

  1. G04.011w.625

AMA Style

References

  1. National Library of Medicine. Chaperone-Mediated Autophagy. Medical Subject Headings (MeSH). 2026. Unique ID D000080642. http://id.nlm.nih.gov/mesh/2026/D000080642
  2. Chaperone-Mediated Autophagy. In: Wikidata. https://www.wikidata.org/wiki/Q22289702