Diseases

Charcot-Marie-Tooth Disease

A hereditary motor and sensory neuropathy transmitted most often as an autosomal dominant trait and characterized by progressive distal wasting and loss of reflexes in the muscles of the legs (and occasionally involving the arms). Onset is usually in the second to fourth decade of life. This condition has been divided into two subtypes, hereditary motor and sensory neuropathy (HMSN) types I and II. HMSN I is associated with abnormal nerve conduction velocities and nerve hypertrophy, features not seen in HMSN II. (Adams et al., Principles of Neurology, 6th ed, p1343)

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A hereditary motor and sensory neuropathy transmitted most often as an autosomal dominant trait and characterized by progressive distal wasting and loss of reflexes in the muscles of the legs (and occasionally involving the arms). Onset is usually in the second to fourth decade of life. This condition has been divided into two subtypes, hereditary motor and sensory neuropathy (HMSN) types I and II. HMSN I is associated with abnormal nerve conduction velocities and nerve hypertrophy, features not seen in HMSN II. (Adams et al., Principles of Neurology, 6th ed, p1343)

MeSH Record

Classification

Broader headings

Related Concepts

Knowledge Graph

Loading graph…

Drag nodes to rearrange; hover to trace links; click a node to open its page.

MeSH Record

See Also

MeSH Record

Synonyms

71 entry terms
  • Atrophy, Muscular, Peroneal
  • Charcot-Marie Disease
  • Charcot-Marie-Tooth Hereditary Neuropathy
  • Charcot-Marie-Tooth Syndrome
  • Muscular Atrophy, Peroneal
  • Peroneal Muscular Atrophy
  • Atrophies, Peroneal Muscular
  • Atrophy, Peroneal Muscular
  • Charcot Marie Disease
  • Charcot Marie Tooth Disease
  • Charcot Marie Tooth Hereditary Neuropathy
  • Charcot Marie Tooth Syndrome
  • Hereditary Neuropathy, Charcot-Marie-Tooth
  • Muscular Atrophies, Peroneal
  • Peroneal Muscular Atrophies
  • Syndrome, Charcot-Marie-Tooth
  • Charcot-Marie-Tooth Disease, Autosomal Dominant, With Focally Folded Myelin Sheaths, Type 1A
  • Charcot-Marie-Tooth Disease, Autosomal Dominant, with Focally Folded Myelin Sheaths, Type 1B
  • Charcot-Marie-Tooth Disease, Demyelinating, Type 1A
  • Charcot-Marie-Tooth Disease, Demyelinating, Type 1B
  • Charcot-Marie-Tooth Disease, Slow Nerve Conduction Type, Linked To Duffy
  • Charcot-Marie-Tooth Disease, Type 1A
  • Charcot-Marie-Tooth Disease, Type 1B
  • Charcot-Marie-Tooth Disease, Type I
  • Charcot-Marie-Tooth Disease, Type IA
  • Charcot-Marie-Tooth Disease, Type IB
  • Charcot-Marie-Tooth Disease, Type II
  • Charcot-Marie-Tooth Neuropathy, Type 1A
  • Charcot-Marie-Tooth Neuropathy, Type 1B
  • HMN Distal Type I
  • HMSN 1A
  • HMSN 1B
  • HMSN I
  • HMSN IA
  • HMSN IB
  • HMSN II
  • HMSN Type I
  • HMSN Type II
  • HMSN1A
  • HMSN1B
  • Hereditary Areflexic Dystasia
  • Hereditary Motor And Sensory Neuropathy IB
  • Hereditary Motor and Sensory Neuropathy 1A
  • Hereditary Motor and Sensory Neuropathy 1B
  • Hereditary Motor and Sensory Neuropathy IA
  • Hereditary Motor and Sensory-Neuropathy Type II
  • Hereditary Motor, and Sensory Neuropathy Type I
  • Hereditary Type I Motor and Sensory Neuropathy
  • Neuropathy, Type I Hereditary Motor and Sensory
  • Neuropathy, Type II Hereditary Motor and Sensory
  • Roussy Levy Hereditary Areflexic Dystasia
  • Roussy-Levy Disease
  • Roussy-Levy Hereditary Areflexic Dystasia
  • Roussy-Levy Syndrome
  • Areflexic Dystasia, Hereditary
  • Areflexic Dystasias, Hereditary
  • Charcot Marie Tooth Disease, Type 1A
  • Charcot Marie Tooth Disease, Type 1B
  • Charcot Marie Tooth Disease, Type I
  • Charcot Marie Tooth Disease, Type IA
  • Charcot Marie Tooth Disease, Type IB
  • Charcot Marie Tooth Disease, Type II
  • Charcot Marie Tooth Neuropathy, Type 1A
  • Charcot Marie Tooth Neuropathy, Type 1B
  • Dystasia, Hereditary Areflexic
  • Dystasias, Hereditary Areflexic
  • Hereditary Areflexic Dystasias
  • Hereditary Motor and Sensory Neuropathy Type II
  • Roussy Levy Disease
  • Roussy Levy Syndrome
  • Syndrome, Roussy-Levy

MeSH Record

Aspects Covered

34 allowable subheadings

Indexed with the subheadings blood, cerebrospinal fluid, chemically induced, classification, complications, diagnosis, diagnostic imaging, diet therapy, drug therapy, economics, embryology, enzymology, epidemiology, ethnology, etiology, genetics, history, immunology, metabolism, microbiology, mortality, nursing, parasitology, pathology, physiopathology, prevention & control, psychology, radiotherapy, rehabilitation, surgery, therapy, urine, veterinary, virology.

MeSH Record

History Note

2000(1966)

MeSH Hierarchy

Tree Numbers

  1. C10w.500w.300w.200w
  2. C10w.574w.500.495w.200w
  3. C10w.668w.829w.800w.300w.200w
  4. C16w.131w.666w.300w.200w
  5. C16w.320w.400.375w.200w

MeSH Record

NLM Classification

WE 550

AMA Style

References

  1. National Library of Medicine. Charcot-Marie-Tooth Disease. Medical Subject Headings (MeSH). 2026. Unique ID D002607. http://id.nlm.nih.gov/mesh/2026/D002607
  2. Charcot-Marie-Tooth Disease. In: Wikipedia. https://en.wikipedia.org/wiki/Charcot%E2%80%93Marie%E2%80%93Tooth_disease
  3. Charcot-Marie-Tooth Disease. In: Wikidata. https://www.wikidata.org/wiki/Q1052687