Structured Summary
Abstract
A serine/threonine-specific protein kinase which is encoded by the CHEK1 gene in humans. Checkpoint kinase 1 (also known as Chk1) coordinates DNA damage response and cell cycle checkpoint response. Under these conditions, activation of Chk1 results in the initiation of cell cycle checkpoints, cell cycle arrest, DNA repair and cell death, to prevent damaged cells from progressing through the cell cycle.
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Classification
Broader headings
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MeSH Record
Synonyms
4 entry terms
- Checkpoint-1 Kinase
- Chk1 Kinase
- Chk1 Protein Kinase
- Protein Kinase, Chk1
MeSH Record
Aspects Covered
29 allowable subheadings
Indexed with the subheadings administration & dosage, adverse effects, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.
MeSH Record
History Note
2017 (2004)
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AMA Style
References
- National Library of Medicine. Checkpoint Kinase 1. Medical Subject Headings (MeSH). 2026. Unique ID D000071877. http://id.nlm.nih.gov/mesh/2026/D000071877
- Checkpoint Kinase 1. In: Wikidata. https://www.wikidata.org/wiki/Q21109168