Diseases

Chediak-Higashi Syndrome

A form of phagocyte bactericidal dysfunction characterized by unusual oculocutaneous albinism, high incidence of lymphoreticular neoplasms, and recurrent pyogenic infections. In many cell types, abnormal lysosomes are present leading to defective pigment distribution and abnormal neutrophil functions. The disease is transmitted by autosomal recessive inheritance and a similar disorder occurs in the beige mouse, the Aleutian mink, and albino Hereford cattle.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A form of phagocyte bactericidal dysfunction characterized by unusual oculocutaneous albinism, high incidence of lymphoreticular neoplasms, and recurrent pyogenic infections. In many cell types, abnormal lysosomes are present leading to defective pigment distribution and abnormal neutrophil functions. The disease is transmitted by autosomal recessive inheritance and a similar disorder occurs in the beige mouse, the Aleutian mink, and albino Hereford cattle.

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Synonyms

5 entry terms
  • Chediak-Steinbrinck-Higashi Syndrome
  • Oculocutaneous Albinism with Leukocyte Defect
  • Chediak Higashi Syndrome
  • Chediak Steinbrinck Higashi Syndrome
  • Chediak-Steinbrinck-Higashi Syndromes

MeSH Record

Aspects Covered

34 allowable subheadings

Indexed with the subheadings blood, cerebrospinal fluid, chemically induced, classification, complications, diagnosis, diagnostic imaging, diet therapy, drug therapy, economics, embryology, enzymology, epidemiology, ethnology, etiology, genetics, history, immunology, metabolism, microbiology, mortality, nursing, parasitology, pathology, physiopathology, prevention & control, psychology, radiotherapy, rehabilitation, surgery, therapy, urine, veterinary, virology.

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History Note

71

MeSH Record

Previous Indexing

  • Immunologic Deficiency Syndromes (1968-1970)
  • Leukocytes (1966-1970)

MeSH Hierarchy

Tree Numbers

  1. C11w.270.040w.772w
  2. C15.378w.553.774w.257w
  3. C16w.320w.798w.375w
  4. C20w.673w.774w.257w
  5. C20w.673w.795w.375w

MeSH Record

NLM Classification

QW 740

AMA Style

References

  1. National Library of Medicine. Chediak-Higashi Syndrome. Medical Subject Headings (MeSH). 2026. Unique ID D002609. http://id.nlm.nih.gov/mesh/2026/D002609
  2. Chediak-Higashi Syndrome. In: Wikipedia. https://en.wikipedia.org/wiki/Ch%C3%A9diak%E2%80%93Higashi_syndrome
  3. Chediak-Higashi Syndrome. In: Wikidata. https://www.wikidata.org/wiki/Q934034