Diseases

Chronic Progressive External Ophthalmoplegia

A mitochondrial myopathy characterized by slowly progressive paralysis of the levator palpebrae, orbicularis oculi, and extraocular muscles. Ragged-red fibers and atrophy are found on muscle biopsy. Familial and sporadic forms may occur. Disease onset is usually in the first or second decade of life, and the illness slowly progresses until usually all ocular motility is lost. (From Adams et al., Principles of Neurology, 6th ed, p1422)

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A mitochondrial myopathy characterized by slowly progressive paralysis of the levator palpebrae, orbicularis oculi, and extraocular muscles. Ragged-red fibers and atrophy are found on muscle biopsy. Familial and sporadic forms may occur. Disease onset is usually in the first or second decade of life, and the illness slowly progresses until usually all ocular motility is lost. (From Adams et al., Principles of Neurology, 6th ed, p1422)

MeSH Record

Classification

Broader headings

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MeSH Record

Synonyms

18 entry terms
  • CPEO
  • Graefe Disease
  • Graefe's Disease
  • Mitochondrial Ocular Myopathy
  • Ocular Muscular Dystrophy
  • Ocular Myopathy of Von Graefe-Fuchs
  • Ophthalmoplegia, Chronic Progressive External
  • Ophthalmoplegia, Progressive External
  • Progressive External Ophthalmoplegia
  • Disease, Graefe
  • Dystrophy, Ocular Muscular
  • External Ophthalmoplegia, Progressive
  • Muscular Dystrophies, Ocular
  • Muscular Dystrophy, Ocular
  • Myopathy, Mitochondrial Ocular
  • Ocular Muscular Dystrophies
  • Ocular Myopathy of Von Graefe Fuchs
  • Ocular Myopathy, Mitochondrial

MeSH Record

Aspects Covered

35 allowable subheadings

Indexed with the subheadings blood, cerebrospinal fluid, chemically induced, classification, complications, congenital, diagnosis, diagnostic imaging, diet therapy, drug therapy, economics, embryology, enzymology, epidemiology, ethnology, etiology, genetics, history, immunology, metabolism, microbiology, mortality, nursing, parasitology, pathology, physiopathology, prevention & control, psychology, radiotherapy, rehabilitation, surgery, therapy, urine, veterinary, virology.

MeSH Record

Indexing Annotation

chronic progressive external ophthalmoplegia with cardiomyopathy & retinitis pigmentosa = KEARNS-SAYRE SYNDROME

MeSH Record

History Note

93

MeSH Record

Previous Indexing

  • DNA, Mitochondrial (1988-1992)
  • Mitochondria, Muscle (1972-1992)
  • Ophthalmoplegia (1966-1992)

MeSH Hierarchy

Tree Numbers

  1. C05w.651w.460w.700w
  2. C10w.292w.562.750w.250w
  3. C10w.597.622w.447w.511w
  4. C10w.668w.491w.500w.700w
  5. C11w.590.472w.250w
  6. C18.452w.660w.560w.700w
  7. C23.550.291.500w.688w
  8. C23.888w.592.636w.447w.511w

AMA Style

References

  1. National Library of Medicine. Chronic Progressive External Ophthalmoplegia. Medical Subject Headings (MeSH). 2026. Unique ID D017246. http://id.nlm.nih.gov/mesh/2026/D017246
  2. Chronic Progressive External Ophthalmoplegia. In: Wikipedia. https://en.wikipedia.org/wiki/Chronic_progressive_external_ophthalmoplegia
  3. Chronic Progressive External Ophthalmoplegia. In: Wikidata. https://www.wikidata.org/wiki/Q2026857