Chemicals and Drugs

Cidofovir

An acyclic nucleoside phosphonate that acts as a competitive inhibitor of viral DNA polymerases. It is used in the treatment of RETINITIS caused by CYTOMEGALOVIRUS INFECTIONS and may also be useful for treating HERPESVIRUS INFECTIONS.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

An acyclic nucleoside phosphonate that acts as a competitive inhibitor of viral DNA polymerases. It is used in the treatment of RETINITIS caused by CYTOMEGALOVIRUS INFECTIONS and may also be useful for treating HERPESVIRUS INFECTIONS.

Chemical Identity

Chemical Information

Molecular Formula
C8H14N3O6P
Molecular Weight
279.19 g/mol
CAS Registry No.
113852-37-2
IUPAC Name
[(2S)-1-(4-amino-2-oxopyrimidin-1-yl)-3-hydroxypropan-2-yl]oxymethylphosphonic acid
InChIKey
VWFCHDSQECPREK-LURJTMIESA-N
SMILES
C1=CN(C(=O)N=C1N)C[C@@H](CO)OCP(=O)(O)O
MeSH Unique ID
D000077404
Source
PubChem CID 60613

MeSH Record

Classification

Broader headings

Related Concepts

Knowledge Graph

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Drug Class

Pharmacological Action

MeSH Record

Synonyms

12 entry terms
  • HPMPC
  • 1-((3-Hydroxy-2-phosphonylmethoxy)propyl)cytosine
  • 1-(3-Hydroxy-2-phosphonylmethoxypropyl)cytosine
  • Cidofovir Anhydrous
  • Cidofovir Sodium
  • Cidofovir, (+-)-isomer
  • Cidofovir, (R)-isomer
  • Cidofovir, Sodium Salt
  • GS 504
  • GS-504
  • Vistide
  • GS504

MeSH Record

Aspects Covered

25 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analogs & derivatives, analysis, antagonists & inhibitors, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, economics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.

MeSH Record

History Note

2019 (1989)

MeSH Hierarchy

Tree Numbers

  1. D02w.705w.429.437w
  2. D03w.383.742.698.421w.216w

AMA Style

References

  1. National Library of Medicine. Cidofovir. Medical Subject Headings (MeSH). 2026. Unique ID D000077404. http://id.nlm.nih.gov/mesh/2026/D000077404
  2. Cidofovir. In: Wikipedia. https://en.wikipedia.org/wiki/Cidofovir
  3. Cidofovir. In: Wikidata. https://www.wikidata.org/wiki/Q423445
  4. Cidofovir. In: PubChem Compound. CID 60613. https://pubchem.ncbi.nlm.nih.gov/compound/60613