Structured Summary
Abstract
Acids, salts, and derivatives of clavulanic acid (C8H9O5N). They consist of those beta-lactam compounds that differ from penicillin in having the sulfur of the thiazolidine ring replaced by an oxygen. They have limited antibacterial action, but block bacterial beta-lactamase irreversibly, so that similar antibiotics are not broken down by the bacterial enzymes and therefore can exert their antibacterial effects.
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Classification
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Drug Class
Pharmacological Action
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Synonyms
1 entry terms
- Acids, Clavulanic
MeSH Record
Aspects Covered
25 allowable subheadings
Indexed with the subheadings administration & dosage, adverse effects, agonists, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, economics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.
MeSH Record
Indexing Annotation
/biosyn permitted if by living matter
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History Note
83
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Previous Indexing
- Amides (1966-1973)
- Amidohydrolases (1966-1978)
- Lactams (1974-1982)
- Penicillinase (1966-1978)
- beta-Lactamases (1979-1982)
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MeSH Record
NLM Classification
QV 350
AMA Style
References
- National Library of Medicine. Clavulanic Acids. Medical Subject Headings (MeSH). 2026. Unique ID D002969. http://id.nlm.nih.gov/mesh/2026/D002969
- Clavulanic Acids. In: Wikidata. https://www.wikidata.org/wiki/Q100989452