Health Care

Clinical Trials Data Monitoring Committees

Committees established to review interim data and efficacy outcomes in clinical trials. The findings of these committees are used in deciding whether a trial should be continued as designed, changed, or terminated. Government regulations regarding federally-funded research involving human subjects (the Common Rule) require (45 CFR 46.111) that research ethics committees reviewing large-scale clinical trials monitor the data collected using a mechanism such as a data monitoring committee. FDA regulations (21 CFR 50.24) require that such committees be established to monitor studies conducted in emergency settings.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

Committees established to review interim data and efficacy outcomes in clinical trials. The findings of these committees are used in deciding whether a trial should be continued as designed, changed, or terminated. Government regulations regarding federally-funded research involving human subjects (the Common Rule) require (45 CFR 46.111) that research ethics committees reviewing large-scale clinical trials monitor the data collected using a mechanism such as a data monitoring committee. FDA regulations (21 CFR 50.24) require that such committees be established to monitor studies conducted in emergency settings.

MeSH Record

Classification

Broader headings

Related Concepts

Knowledge Graph

Loading graph…

Drag nodes to rearrange; hover to trace links; click a node to open its page.

MeSH Record

See Also

MeSH Record

Synonyms

13 entry terms
  • Data Monitoring Committees
  • Data and Safety Monitoring Boards
  • Safety Monitoring Boards
  • Board, Safety Monitoring
  • Boards, Safety Monitoring
  • Committee, Data Monitoring
  • Committees, Data Monitoring
  • Data Monitoring Committee
  • Monitoring Board, Safety
  • Monitoring Boards, Safety
  • Monitoring Committee, Data
  • Monitoring Committees, Data
  • Safety Monitoring Board

MeSH Record

Aspects Covered

9 allowable subheadings

Indexed with the subheadings classification, economics, ethics, history, legislation & jurisprudence, organization & administration, standards, statistics & numerical data, trends.

MeSH Record

History Note

2002

MeSH Record

Previous Indexing

  • Clinical Trials (1991-2001)
  • Professional Staff Committees (1991-2001)

MeSH Hierarchy

Tree Number

  1. N05.700.685.149

AMA Style

References

  1. National Library of Medicine. Clinical Trials Data Monitoring Committees. Medical Subject Headings (MeSH). 2026. Unique ID D026661. http://id.nlm.nih.gov/mesh/2026/D026661
  2. Clinical Trials Data Monitoring Committees. In: Wikidata. https://www.wikidata.org/wiki/Q70348822