Chemicals and Drugs

Clonazepam

An anticonvulsant used for several types of seizures, including myotonic or atonic seizures, photosensitive epilepsy, and absence seizures, although tolerance may develop. It is seldom effective in generalized tonic-clonic or partial seizures. The mechanism of action appears to involve the enhancement of GAMMA-AMINOBUTYRIC ACID receptor responses.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

An anticonvulsant used for several types of seizures, including myotonic or atonic seizures, photosensitive epilepsy, and absence seizures, although tolerance may develop. It is seldom effective in generalized tonic-clonic or partial seizures. The mechanism of action appears to involve the enhancement of GAMMA-AMINOBUTYRIC ACID receptor responses.

Chemical Identity

Chemical Information

Molecular Formula
C15H10ClN3O3
Molecular Weight
315.71 g/mol
CAS Registry No.
1622-61-3
IUPAC Name
5-(2-chlorophenyl)-7-nitro-1,3-dihydro-1,4-benzodiazepin-2-one
InChIKey
DGBIGWXXNGSACT-UHFFFAOYSA-N
SMILES
C1C(=O)NC2=C(C=C(C=C2)[N+](=O)[O-])C(=N1)C3=CC=CC=C3Cl
MeSH Unique ID
D002998
Source
PubChem CID 2802

MeSH Record

Classification

Broader headings

Related Concepts

Knowledge Graph

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Drug Class

Pharmacological Action

MeSH Record

Synonyms

6 entry terms
  • 2H-1,4-Benzodiazepin-2-one, 5-(2-chlorophenyl)-1,3-dihydro-7-nitro-
  • Antelepsin
  • Klonopin
  • Rivotril
  • Ro 5-4023
  • Ro 54023

MeSH Record

Aspects Covered

25 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analogs & derivatives, analysis, antagonists & inhibitors, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, economics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.

MeSH Record

History Note

87(75); was see under BENZODIAZEPINONES 1975-86

MeSH Record

Previous Indexing

  • Benzodiazepinones (1974)
  • Chlorobenzenes (1974)
  • Nitro Compounds (1974)

MeSH Hierarchy

Tree Number

  1. D03w.633.100.079.080w.070.150w

AMA Style

References

  1. National Library of Medicine. Clonazepam. Medical Subject Headings (MeSH). 2026. Unique ID D002998. http://id.nlm.nih.gov/mesh/2026/D002998
  2. Clonazepam. In: Wikipedia. https://en.wikipedia.org/wiki/Clonazepam
  3. Clonazepam. In: Wikidata. https://www.wikidata.org/wiki/Q407988
  4. Clonazepam. In: PubChem Compound. CID 2802. https://pubchem.ncbi.nlm.nih.gov/compound/2802