Structured Summary
Abstract
An imidazole derivative with a broad spectrum of antimycotic activity. It inhibits biosynthesis of the sterol ergostol, an important component of fungal CELL MEMBRANES. Its action leads to increased membrane permeability and apparent disruption of enzyme systems bound to the membrane.
Chemical Identity
Chemical Information
- Molecular Formula
- C22H17ClN2
- Molecular Weight
- 344.8 g/mol
- CAS Registry No.
- 23593-75-1
- IUPAC Name
- 1-[(2-chlorophenyl)-diphenylmethyl]imidazole
- InChIKey
- VNFPBHJOKIVQEB-UHFFFAOYSA-N
- SMILES
- C1=CC=C(C=C1)C(C2=CC=CC=C2)(C3=CC=CC=C3Cl)N4C=CN=C4
- MeSH Unique ID
- D003022
- Source
- PubChem CID 2812
MeSH Record
Classification
Broader headings
Related Concepts
Knowledge Graph
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Drug Class
Pharmacological Action
MeSH Record
Synonyms
7 entry terms
- Klotrimazole
- Bay b 5097
- Canesten
- FB b 5097
- Kanesten
- Lotrimin
- Mycelex
MeSH Record
Aspects Covered
25 allowable subheadings
Indexed with the subheadings administration & dosage, adverse effects, agonists, analogs & derivatives, analysis, antagonists & inhibitors, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, economics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.
MeSH Record
History Note
91(75); was see under IMIDAZOLES 1975-90
MeSH Record
Previous Indexing
- Imidazoles (1971-1974)
- Trityl Compounds (1974)
MeSH Hierarchy
Tree Number
AMA Style
References
- National Library of Medicine. Clotrimazole. Medical Subject Headings (MeSH). 2026. Unique ID D003022. http://id.nlm.nih.gov/mesh/2026/D003022
- Clotrimazole. In: Wikipedia. https://en.wikipedia.org/wiki/Clotrimazole
- Clotrimazole. In: Wikidata. https://www.wikidata.org/wiki/Q413546
- Clotrimazole. In: PubChem Compound. CID 2812. https://pubchem.ncbi.nlm.nih.gov/compound/2812