Structured Summary
Abstract
A carbamate and thiazole derivative that functions as a CYTOCHROME P450 CYP3A INHIBITOR to enhance the concentration of ANTI-HIV AGENTS, with which it is used in combination, for the treatment of HIV INFECTIONS.
Chemical Identity
Chemical Information
- Molecular Formula
- C40H53N7O5S2
- Molecular Weight
- 776.0 g/mol
- CAS Registry No.
- 1004316-88-4
- IUPAC Name
- 1,3-thiazol-5-ylmethyl N-[(2R,5R)-5-[[(2S)-2-[[methyl-[(2-propan-2-yl-1,3-thiazol-4-yl)methyl]carbamoyl]amino]-4-morpholin-4-ylbutanoyl]amino]-1,6-diphenylhexan-2-yl]carbamate
- InChIKey
- ZCIGNRJZKPOIKD-CQXVEOKZSA-N
- SMILES
- CC(C)C1=NC(=CS1)CN(C)C(=O)N[C@@H](CCN2CCOCC2)C(=O)N[C@H](CC[C@H](CC3=CC=CC=C3)NC(=O)OCC4=CN=CS4)CC5=CC=CC=C5
- MeSH Unique ID
- D000069547
- Source
- PubChem CID 25151504
MeSH Record
Classification
Broader headings
Related Concepts
Knowledge Graph
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Drug Class
Pharmacological Action
MeSH Record
Synonyms
5 entry terms
- GS 9350
- GS-9350
- GS9350
- Tybost
- 9350, GS
MeSH Record
Aspects Covered
25 allowable subheadings
Indexed with the subheadings administration & dosage, adverse effects, agonists, analogs & derivatives, analysis, antagonists & inhibitors, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, economics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.
MeSH Record
History Note
2016 (2011)
MeSH Hierarchy
Tree Numbers
AMA Style
References
- National Library of Medicine. Cobicistat. Medical Subject Headings (MeSH). 2026. Unique ID D000069547. http://id.nlm.nih.gov/mesh/2026/D000069547
- Cobicistat. In: Wikipedia. https://en.wikipedia.org/wiki/Cobicistat
- Cobicistat. In: Wikidata. https://www.wikidata.org/wiki/Q5138908
- Cobicistat. In: PubChem Compound. CID 25151504. https://pubchem.ncbi.nlm.nih.gov/compound/25151504