Chemicals and Drugs

Cobra Cardiotoxin Proteins

Most abundant proteins in COBRA venom; basic polypeptides of 57 to 62 amino acids with four disulfide bonds and a molecular weight of less than 7000; causes skeletal and cardiac muscle contraction, interferes with neuromuscular and ganglionic transmission, depolarizes nerve, muscle and blood cell membranes, thus causing hemolysis.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

Most abundant proteins in COBRA venom; basic polypeptides of 57 to 62 amino acids with four disulfide bonds and a molecular weight of less than 7000; causes skeletal and cardiac muscle contraction, interferes with neuromuscular and ganglionic transmission, depolarizes nerve, muscle and blood cell membranes, thus causing hemolysis.

MeSH Record

Classification

Broader headings

Related Concepts

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MeSH Record

Synonyms

21 entry terms
  • Cobra Cardiotoxin
  • Cobra Cytotoxin Proteins
  • Direct Lytic Factors
  • Cardiotoxin Proteins, Cobra
  • Cardiotoxin, Cobra
  • Cytotoxin Proteins, Cobra
  • Lytic Factors, Direct
  • Cardiotoxin I
  • Cardiotoxin II
  • Cardiotoxin VII 4
  • Cardiotoxin VII2
  • Cardiotoxin-Like Basic Polypeptide
  • Cardiotoxins, Elapid
  • Cobra Toxin Gamma
  • Cobra Venom Cardiotoxin D
  • Cytotoxin-Like Basic Protein (Cobra Venom)
  • Basic Polypeptide, Cardiotoxin-Like
  • Cardiotoxin Like Basic Polypeptide
  • Elapid Cardiotoxins
  • Polypeptide, Cardiotoxin-Like Basic
  • Toxin Gamma, Cobra

MeSH Record

Aspects Covered

27 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.

MeSH Record

Indexing Annotation

/antag permitted but consider also ANTIVENINS

MeSH Record

History Note

2008(1978)

MeSH Record

Previous Indexing

  • Peptides (1966-1977)
  • Proteins (1966-1977)
  • Snake Venoms (1975-1977)
  • Snakes (1966-1974)
  • Venoms (1966-1974)

MeSH Hierarchy

Tree Numbers

  1. D12.776w.831.222
  2. D20.888w.850w.325.180
  3. D23.946w.833w.850w.325.180

AMA Style

References

  1. National Library of Medicine. Cobra Cardiotoxin Proteins. Medical Subject Headings (MeSH). 2026. Unique ID D004179. http://id.nlm.nih.gov/mesh/2026/D004179
  2. Cobra Cardiotoxin Proteins. In: Wikidata. https://www.wikidata.org/wiki/Q78447359