Chemicals and Drugs

Colforsin

Potent activator of the adenylate cyclase system and the biosynthesis of cyclic AMP. From the plant COLEUS FORSKOHLII. Has antihypertensive, positive inotropic, platelet aggregation inhibitory, and smooth muscle relaxant activities; also lowers intraocular pressure and promotes release of hormones from the pituitary gland.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

Potent activator of the adenylate cyclase system and the biosynthesis of cyclic AMP. From the plant COLEUS FORSKOHLII. Has antihypertensive, positive inotropic, platelet aggregation inhibitory, and smooth muscle relaxant activities; also lowers intraocular pressure and promotes release of hormones from the pituitary gland.

Chemical Identity

Chemical Information

Molecular Formula
C22H34O7
Molecular Weight
410.5 g/mol
CAS Registry No.
66575-29-9
IUPAC Name
[(3R,4aR,5S,6S,6aS,10S,10aR,10bS)-3-ethenyl-6,10,10b-trihydroxy-3,4a,7,7,10a-pentamethyl-1-oxo-5,6,6a,8,9,10-hexahydro-2H-benzo[f]chromen-5-yl] acetate
InChIKey
OHCQJHSOBUTRHG-KGGHGJDLSA-N
SMILES
CC(=O)O[C@H]1[C@H]([C@@H]2[C@]([C@H](CCC2(C)C)O)([C@@]3([C@@]1(O[C@@](CC3=O)(C)C=C)C)O)C)O
MeSH Unique ID
D005576
Source
PubChem CID 47936

MeSH Record

Classification

Broader headings

Related Concepts

Knowledge Graph

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Drug Class

Pharmacological Action

MeSH Record

Synonyms

6 entry terms
  • Coleonol
  • Forskolin
  • N,N-Dimethyl-beta-alanine-5-(acetyloxy)-3-ethenyldodecahydro-10,10b-dihydroxy-3,4a,7,7,10a-pentamethyl-1-oxo-1H-naphtho(2,1-b)pyran-6-yl Ester HCl
  • NKH 477
  • NKH-477
  • NKH477

MeSH Record

Aspects Covered

25 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analogs & derivatives, analysis, antagonists & inhibitors, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, economics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.

MeSH Record

History Note

2014(1986)

MeSH Record

Previous Indexing

  • Diterpenes (1974-1985)
  • Terpenes (1966-1973)

MeSH Hierarchy

Tree Number

  1. D02w.455w.849w.291w.300w

AMA Style

References

  1. National Library of Medicine. Colforsin. Medical Subject Headings (MeSH). 2026. Unique ID D005576. http://id.nlm.nih.gov/mesh/2026/D005576
  2. Colforsin. In: Wikipedia. https://en.wikipedia.org/wiki/Forskolin
  3. Colforsin. In: Wikidata. https://www.wikidata.org/wiki/Q412747
  4. Colforsin. In: PubChem Compound. CID 47936. https://pubchem.ncbi.nlm.nih.gov/compound/47936