Structured Summary
Abstract
A 77-kDa subcomponent of complement C1, encoded by gene C1S, is a SERINE PROTEASE existing as a proenzyme (homodimer) in the intact complement C1 complex. Upon the binding of COMPLEMENT C1Q to antibodies, the activated COMPLEMENT C1R cleaves C1s into two chains, A (heavy) and B (light, the serine protease), linked by disulfide bonds yielding the active C1s. The activated C1s, in turn, cleaves COMPLEMENT C2 and COMPLEMENT C4 to form C4b2a (CLASSICAL C3 CONVERTASE).
MeSH Record
Classification
Broader headings
Related Concepts
Knowledge Graph
Drag nodes to rearrange; hover to trace links; click a node to open its page.
Drug Class
Pharmacological Action
MeSH Record
Synonyms
12 entry terms
- C 1 Esterase
- C1 Esterase
- C1s Complement
- Complement 1 Esterase
- Complement 1s
- Complement Component 1s
- C1s, Complement
- Complement, C1s
- Component 1s, Complement
- Esterase, C 1
- Esterase, C1
- Esterase, Complement 1
MeSH Record
Aspects Covered
29 allowable subheadings
Indexed with the subheadings administration & dosage, adverse effects, agonists, analysis, antagonists & inhibitors, biosynthesis, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.
MeSH Record
History Note
2006 (1978)
MeSH Record
Previous Indexing
- Complement 1 (1975-1977)
- Esterases (1966-1977)
MeSH Hierarchy
Tree Numbers
AMA Style
References
- National Library of Medicine. Complement C1s. Medical Subject Headings (MeSH). 2026. Unique ID D003173. http://id.nlm.nih.gov/mesh/2026/D003173
- Complement C1s. In: Wikidata. https://www.wikidata.org/wiki/Q21111743