Chemicals and Drugs

Complement C3 Nephritic Factor

An IgG autoantibody against the ALTERNATIVE PATHWAY C3 CONVERTASE, found in serum of patients with MESANGIOCAPILLARY GLOMERULONEPHRITIS. The binding of this autoantibody to C3bBb stabilizes the enzyme thus reduces the actions of C3b inactivators (COMPLEMENT FACTOR H; COMPLEMENT FACTOR I). This abnormally stabilized enzyme induces a continuous COMPLEMENT ACTIVATION and generation of C3b thereby promoting the assembly of MEMBRANE ATTACK COMPLEX and cytolysis.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

An IgG autoantibody against the ALTERNATIVE PATHWAY C3 CONVERTASE, found in serum of patients with MESANGIOCAPILLARY GLOMERULONEPHRITIS. The binding of this autoantibody to C3bBb stabilizes the enzyme thus reduces the actions of C3b inactivators (COMPLEMENT FACTOR H; COMPLEMENT FACTOR I). This abnormally stabilized enzyme induces a continuous COMPLEMENT ACTIVATION and generation of C3b thereby promoting the assembly of MEMBRANE ATTACK COMPLEX and cytolysis.

MeSH Record

Classification

Broader headings

Related Concepts

Knowledge Graph

Loading graph…

Drag nodes to rearrange; hover to trace links; click a node to open its page.

Drug Class

Pharmacological Action

MeSH Record

Synonyms

10 entry terms
  • C 3 Nephritic Factor
  • C3 NeF
  • C3 NeF IgG Autoantibodies
  • C3 NeF IgG Autoantibody
  • C3 Nephritic Factor
  • C3NeF IgG Autoantibodies
  • C3NeF IgG Autoantibody
  • Complement 3 Nephritic Factor
  • Autoantibody, C3NeF IgG
  • IgG Autoantibody, C3NeF

MeSH Record

Aspects Covered

29 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analysis, antagonists & inhibitors, biosynthesis, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

History Note

2006 (1978)

MeSH Record

Previous Indexing

  • Blood Proteins (1966-1977)
  • Complement 3 (1975-1977)

MeSH Hierarchy

Tree Numbers

  1. D12.776w.124w.486.274.920.287
  2. D12.776w.124w.486.485.114w.323w.300
  3. D12.776w.124w.790.651.114w.323w.300
  4. D12.776w.377w.715.548.114w.323w.300

AMA Style

References

  1. National Library of Medicine. Complement C3 Nephritic Factor. Medical Subject Headings (MeSH). 2026. Unique ID D003178. http://id.nlm.nih.gov/mesh/2026/D003178
  2. Complement C3 Nephritic Factor. In: Wikidata. https://www.wikidata.org/wiki/Q78122520