Structured Summary
Abstract
A 150-kDa serum glycoprotein composed of three subunits with each encoded by a different gene (C8A; C8B; and C8G). This heterotrimer contains a disulfide-linked C8alpha-C8gamma heterodimer and a noncovalently associated C8beta chain. C8 is the next component to bind the C5-7 complex forming C5b-8 that binds COMPLEMENT C9 and acts as a catalyst in the polymerization of C9.
MeSH Record
Classification
Broader headings
Related Concepts
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Drug Class
Pharmacological Action
MeSH Record
Synonyms
12 entry terms
- C8 Complement
- Complement 8
- Complement Component 8
- C8, Complement
- Complement, C8
- Component 8, Complement
- Complement Component C8 alpha
- Complement Component C8 alpha Chain
- Complement Component C8 beta
- Complement Component C8 beta Chain
- Complement Component C8 gamma
- Complement Component C8 gamma Chain
MeSH Record
Aspects Covered
29 allowable subheadings
Indexed with the subheadings administration & dosage, adverse effects, agonists, analysis, antagonists & inhibitors, biosynthesis, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.
MeSH Record
History Note
2006 (1975)
MeSH Record
Previous Indexing
- Bacteriolysis (1966-1974)
- Complement (1968-1974)
- Hemolysis (1966-1974)
MeSH Hierarchy
Tree Number
AMA Style
References
- National Library of Medicine. Complement C8. Medical Subject Headings (MeSH). 2026. Unique ID D003185. http://id.nlm.nih.gov/mesh/2026/D003185
- Complement C8. In: Wikipedia. https://en.wikipedia.org/wiki/C8_complex
- Complement C8. In: Wikidata. https://www.wikidata.org/wiki/Q5008394