Chemicals and Drugs

Complement Factor B

A glycine-rich, heat-labile serum glycoprotein that contains a component of the C3 CONVERTASE ALTERNATE PATHWAY (C3bBb). Bb, a serine protease, is generated when factor B is cleaved by COMPLEMENT FACTOR D into Ba and Bb.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A glycine-rich, heat-labile serum glycoprotein that contains a component of the C3 CONVERTASE ALTERNATE PATHWAY (C3bBb). Bb, a serine protease, is generated when factor B is cleaved by COMPLEMENT FACTOR D into Ba and Bb.

MeSH Record

Classification

Broader headings

Related Concepts

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Drug Class

Pharmacological Action

MeSH Record

Synonyms

29 entry terms
  • C3 Proactivator
  • C3PA
  • Complement 3 Proactivator
  • Complement Factor B, Alternative Pathway
  • Complement Protein B
  • Complement Protein Factor B
  • Factor B
  • Properdin Factor B
  • Factor B, Complement
  • Factor B, Properdin
  • Proactivator, C3
  • Proactivator, Complement 3
  • Protein B, Complement
  • Bb Fragment of Factor B
  • Complement Factor B Fragment, Bb
  • Complement Factor B-Derived Fragment Bb
  • Complement Factor Ba
  • Complement Factor Bb
  • Properdin Factor Ba
  • Properdin Factor Bb
  • Properdin Factor Bf
  • Properdin Factor Bf F1
  • Bb, Complement Factor
  • Complement Factor B Derived Fragment Bb
  • Factor Ba, Complement
  • Factor Ba, Properdin
  • Factor Bb, Complement
  • Factor Bb, Properdin
  • Factor Bf, Properdin

MeSH Record

Aspects Covered

28 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, analysis, antagonists & inhibitors, biosynthesis, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

History Note

99(78)

MeSH Record

Previous Indexing

  • Complement 3 (1975-1977)
  • Enzyme Precursors (1966-1977)
  • Glycoproteins (1966-1977)

MeSH Hierarchy

Tree Numbers

  1. D08.622w.200
  2. D08.811w.277w.656w.300w.760.198
  3. D08.811w.277w.656w.959w.350.198
  4. D12.776w.124w.486.274.900
  5. D12.776w.811w.243w.200

AMA Style

References

  1. National Library of Medicine. Complement Factor B. Medical Subject Headings (MeSH). 2026. Unique ID D011415. http://id.nlm.nih.gov/mesh/2026/D011415
  2. Complement Factor B. In: Wikidata. https://www.wikidata.org/wiki/Q24721664