Structured Summary
Abstract
Peptide neurotoxins from the marine fish-hunting snails of the genus CONUS. They contain 13 to 29 amino acids which are strongly basic and are highly cross-linked by disulfide bonds. There are three types of conotoxins, omega-, alpha-, and mu-. OMEGA-CONOTOXINS inhibit voltage-activated entry of calcium into the presynaptic membrane and therefore the release of ACETYLCHOLINE. Alpha-conotoxins inhibit the postsynaptic acetylcholine receptor. Mu-conotoxins prevent the generation of muscle action potentials. (From Concise Encyclopedia Biochemistry and Molecular Biology, 3rd ed)
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Drug Class
Pharmacological Action
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Synonyms
9 entry terms
- Conotoxin
- alpha-Conotoxin
- alpha-Conotoxins
- mu-Conotoxin
- mu-Conotoxins
- alpha Conotoxin
- alpha Conotoxins
- mu Conotoxin
- mu Conotoxins
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Aspects Covered
24 allowable subheadings
Indexed with the subheadings administration & dosage, adverse effects, agonists, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, poisoning, radiation effects, therapeutic use, toxicity, urine.
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Indexing Annotation
OMEGA-CONOTOXINS and OMEGA-CONOTOXIN GVIA are available
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History Note
2000
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Previous Indexing
- Mollusk Venoms (1986-1999)
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AMA Style
References
- National Library of Medicine. Conotoxins. Medical Subject Headings (MeSH). 2026. Unique ID D020916. http://id.nlm.nih.gov/mesh/2026/D020916
- Conotoxins. In: Wikipedia. https://en.wikipedia.org/wiki/Conotoxin
- Conotoxins. In: Wikidata. https://www.wikidata.org/wiki/Q417238