Structured Summary
Abstract
A class I viral fusion protein that forms the characteristic spikes, or peplomers, found on the viral surface that mediate virus attachment, fusion, and entry into the host cell. During virus maturation, it is cleaved into two subunits: S1, which binds to receptors in the host cell, and S2, which mediates membrane fusion.
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Classification
Broader headings
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Synonyms
9 entry terms
- Glycoprotein S, Coronavirus
- Spike Glycoprotein, Coronavirus
- Spike Glycoproteins, Coronavirus
- Spike Protein, Coronavirus
- Coronavirus Spike Protein
- E2 Spike Glycoprotein, Coronavirus
- Spike Glycoprotein S1, Coronavirus
- Spike Glycoprotein, Bovine Coronavirus
- Spike Protein S2, Coronavirus
MeSH Record
Aspects Covered
30 allowable subheadings
Indexed with the subheadings administration & dosage, adverse effects, agonists, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.
MeSH Record
History Note
2014
MeSH Record
Previous Indexing
- Membrane Glycoproteins (1991-2013)
- Viral Envelope Proteins (1983-2013)
- Viral Proteins (1979-1982)
MeSH Hierarchy
Tree Numbers
AMA Style
References
- National Library of Medicine. Coronavirus Spike Glycoprotein. Medical Subject Headings (MeSH). 2026. Unique ID D064370. http://id.nlm.nih.gov/mesh/2026/D064370
- Coronavirus Spike Glycoprotein. In: Wikipedia. https://en.wikipedia.org/wiki/Coronavirus_spike_protein
- Coronavirus Spike Glycoprotein. In: Wikidata. https://www.wikidata.org/wiki/Q108250944