Chemicals and Drugs

Cortisone

A naturally occurring glucocorticoid that has been used in replacement therapy for ADRENAL INSUFFICIENCY and as an anti-inflammatory agent. Cortisone itself is inactive; it is converted in the liver to the active metabolite HYDROCORTISONE. (From Martindale, The Extra Pharmacopoeia, 30th ed, p726)

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A naturally occurring glucocorticoid that has been used in replacement therapy for ADRENAL INSUFFICIENCY and as an anti-inflammatory agent. Cortisone itself is inactive; it is converted in the liver to the active metabolite HYDROCORTISONE. (From Martindale, The Extra Pharmacopoeia, 30th ed, p726)

Chemical Identity

Chemical Information

Molecular Formula
C21H28O5
Molecular Weight
360.4 g/mol
CAS Registry No.
53-06-5
IUPAC Name
(8S,9S,10R,13S,14S,17R)-17-hydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-1,2,6,7,8,9,12,14,15,16-decahydrocyclopenta[a]phenanthrene-3,11-dione
InChIKey
MFYSYFVPBJMHGN-ZPOLXVRWSA-N
SMILES
C[C@]12CCC(=O)C=C1CC[C@@H]3[C@@H]2C(=O)C[C@]4([C@H]3CC[C@@]4(C(=O)CO)O)C
MeSH Unique ID
D003348
Source
PubChem CID 222786

MeSH Record

Classification

Broader headings

Related Concepts

Knowledge Graph

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Drug Class

Pharmacological Action

MeSH Record

Synonyms

4 entry terms
  • 17-Hydroxy-3,11,20-trioxopregn-4-en-21-yl acetate
  • Adreson
  • Cortisone Acetate
  • Cortone Acetate

MeSH Record

Aspects Covered

29 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analogs & derivatives, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.

MeSH Record

History Note

/adv eff-pois-tox was CORTISONE TOXICOLOGY 1963-65; /ther use was CORTISONE, THERAPEUTIC 1965

MeSH Hierarchy

Tree Numbers

  1. D04w.210.500w.745.745w.183w
  2. D06.472w.040.585w.478.195w

MeSH Record

NLM Classification

WK 755

AMA Style

References

  1. National Library of Medicine. Cortisone. Medical Subject Headings (MeSH). 2026. Unique ID D003348. http://id.nlm.nih.gov/mesh/2026/D003348
  2. Cortisone. In: Wikipedia. https://en.wikipedia.org/wiki/Cortisone
  3. Cortisone. In: Wikidata. https://www.wikidata.org/wiki/Q423185
  4. Cortisone. In: PubChem Compound. CID 222786. https://pubchem.ncbi.nlm.nih.gov/compound/222786