Chemicals and Drugs

Cyclic GMP

Guanosine cyclic 3',5'-(hydrogen phosphate). A guanine nucleotide containing one phosphate group which is esterified to the sugar moiety in both the 3'- and 5'-positions. It is a cellular regulatory agent and has been described as a second messenger. Its levels increase in response to a variety of hormones, including acetylcholine, insulin, and oxytocin and it has been found to activate specific protein kinases. (From Merck Index, 11th ed)

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

Guanosine cyclic 3',5'-(hydrogen phosphate). A guanine nucleotide containing one phosphate group which is esterified to the sugar moiety in both the 3'- and 5'-positions. It is a cellular regulatory agent and has been described as a second messenger. Its levels increase in response to a variety of hormones, including acetylcholine, insulin, and oxytocin and it has been found to activate specific protein kinases. (From Merck Index, 11th ed)

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MeSH Record

Synonyms

11 entry terms
  • Guanosine Cyclic 3',5'-Monophosphate
  • Guanosine Cyclic 3,5 Monophosphate
  • Guanosine Cyclic Monophosphate
  • Guanosine Cyclic-3',5'-Monophosphate
  • 3',5'-Monophosphate, Guanosine Cyclic
  • Cyclic 3',5'-Monophosphate, Guanosine
  • Cyclic Monophosphate, Guanosine
  • Cyclic-3',5'-Monophosphate, Guanosine
  • GMP, Cyclic
  • Guanosine Cyclic 3',5' Monophosphate
  • Monophosphate, Guanosine Cyclic

MeSH Record

Aspects Covered

29 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analogs & derivatives, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.

MeSH Record

History Note

94; was GUANOSINE CYCLIC MONOPHOSPHATE 1980-93, was GUANOSINE CYCLIC-3',5'-MONOPHOSPHATE 1978-79, was GUANOSINE CYCLIC 3',5' MONOPHOSPHATE 1971-77 (Prov 1971); CYCLIC GMP was see GUANOSINE CYCLIC MONOPHOSPHATE 1975-93; GUANOSINE CYCLIC 2',3'-MONOPHOSPHATE was see GUANOSINE CYCLIC MONOPHOSPHATE 1980-93

MeSH Record

Previous Indexing

  • Guanine Nucleotides (1966-1971)

MeSH Hierarchy

Tree Numbers

  1. D03w.633.100.759.646.454.160w
  2. D13.695w.462w.275w
  3. D13.695w.667.454.160w
  4. D13.695w.827w.426.160w

MeSH Record

NLM Classification

QU 57

AMA Style

References

  1. National Library of Medicine. Cyclic GMP. Medical Subject Headings (MeSH). 2026. Unique ID D006152. http://id.nlm.nih.gov/mesh/2026/D006152
  2. Cyclic GMP. In: Wikipedia. https://en.wikipedia.org/wiki/Cyclic_guanosine_monophosphate
  3. Cyclic GMP. In: Wikidata. https://www.wikidata.org/wiki/Q422511