Structured Summary
Abstract
A nucleotidyltransferase that catalyzes the formation of cyclic GMP-AMP in mammals. This activates the STING1 PROTEIN through the CGAS-STING SIGNALING PATHWAY, which triggers the production of INTERFERON TYPE I and other CYTOKINES.
MeSH Record
Classification
Broader headings
Related Concepts
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MeSH Record
Synonyms
2 entry terms
- Cyclic GMP-AMP Synthase
- cGAS Protein
MeSH Record
Aspects Covered
29 allowable subheadings
Indexed with the subheadings administration & dosage, adverse effects, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.
MeSH Record
History Note
2026
MeSH Record
Previous Indexing
- Nucleotidyltransferases (2013-2025)
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Tree Number
AMA Style
References
- National Library of Medicine. Cyclic Guanosine Monophosphate-Adenosine Monophosphate Synthase. Medical Subject Headings (MeSH). 2026. Unique ID D000099235. http://id.nlm.nih.gov/mesh/2026/D000099235
- Cyclic Guanosine Monophosphate-Adenosine Monophosphate Synthase. In: Wikipedia. https://en.wikipedia.org/wiki/Cyclic_GMP-AMP_synthase
- Cyclic Guanosine Monophosphate-Adenosine Monophosphate Synthase. In: Wikidata. https://www.wikidata.org/wiki/Q108841452