Chemicals and Drugs

Cyclin-Dependent Kinase 2

A key regulator of CELL CYCLE progression. It partners with CYCLIN E to regulate entry into S PHASE and also interacts with CYCLIN A to phosphorylate RETINOBLASTOMA PROTEIN. Its activity is inhibited by CYCLIN-DEPENDENT KINASE INHIBITOR P27 and CYCLIN-DEPENDENT KINASE INHIBITOR P21.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A key regulator of CELL CYCLE progression. It partners with CYCLIN E to regulate entry into S PHASE and also interacts with CYCLIN A to phosphorylate RETINOBLASTOMA PROTEIN. Its activity is inhibited by CYCLIN-DEPENDENT KINASE INHIBITOR P27 and CYCLIN-DEPENDENT KINASE INHIBITOR P21.

MeSH Record

Classification

Broader headings

Related Concepts

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MeSH Record

Synonyms

6 entry terms
  • CDK2 Protein
  • Cdc2-Related Protein Kinase
  • Cdk2 Protein Kinase
  • p33cdk2 Kinase
  • Cdc2 Related Protein Kinase
  • Cyclin Dependent Kinase 2

MeSH Record

Aspects Covered

29 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

History Note

2006(1991)

MeSH Hierarchy

Tree Numbers

  1. D08.811w.913w.696w.620.682w.700w.646.500w.750
  2. D12.776w.167.200w.323
  3. D12.776w.476.563w.646.500w.750

AMA Style

References

  1. National Library of Medicine. Cyclin-Dependent Kinase 2. Medical Subject Headings (MeSH). 2026. Unique ID D051357. http://id.nlm.nih.gov/mesh/2026/D051357
  2. Cyclin-Dependent Kinase 2. In: Wikidata. https://www.wikidata.org/wiki/Q511968