Structured Summary
Abstract
A cyclin-dependent kinase inhibitor that coordinates the activation of CYCLIN and CYCLIN-DEPENDENT KINASES during the CELL CYCLE. It interacts with active CYCLIN D complexed to CYCLIN-DEPENDENT KINASE 4 in proliferating cells, while in arrested cells it binds and inhibits CYCLIN E complexed to CYCLIN-DEPENDENT KINASE 2.
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Classification
Broader headings
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Drug Class
Pharmacological Action
MeSH Record
Synonyms
12 entry terms
- CDK Inhibitor p27
- CDKN1B Protein
- CDKN4 Protein
- Cyclin-Dependent Kinase Inhibitor 1B
- p27 CDK Inhibitor
- p27 Kip1 Protein
- p27Kip1 Protein
- CDK Inhibitor, p27
- Cyclin Dependent Kinase Inhibitor 1B
- Cyclin Dependent Kinase Inhibitor p27
- Kip1 Protein, p27
- p27, CDK Inhibitor
MeSH Record
Aspects Covered
30 allowable subheadings
Indexed with the subheadings administration & dosage, adverse effects, agonists, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.
MeSH Record
History Note
2006(1992)
MeSH Hierarchy
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AMA Style
References
- National Library of Medicine. Cyclin-Dependent Kinase Inhibitor p27. Medical Subject Headings (MeSH). 2026. Unique ID D050760. http://id.nlm.nih.gov/mesh/2026/D050760
- Cyclin-Dependent Kinase Inhibitor p27. In: Wikidata. https://www.wikidata.org/wiki/Q24741228