D-Penicillamine (2,5)- Enkephalin

Structured Summary

Abstract

A disulfide opioid pentapeptide that selectively binds to the DELTA OPIOID RECEPTOR. It possesses antinociceptive activity.

Chemical Identity

Chemical Information

Molecular Formula: C₃₀H₃₉N₅O₇S₂
Molecular Weight: 645.8 g/mol
CAS Registry No.: 88373-73-3
IUPAC Name: (4S,7S,13S)-13-[[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]amino]-7-benzyl-3,3,14,14-tetramethyl-6,9,12-trioxo-1,2-dithia-5,8,11-triazacyclotetradecane-4-carboxylic acid
InChIKey: MCMMCRYPQBNCPH-WMIMKTLMSA-N
SMILES: CC1([C@H](C(=O)NCC(=O)N[C@H](C(=O)N[C@H](C(SS1)(C)C)C(=O)O)CC2=CC=CC=C2)NC(=O)[C@H](CC3=CC=C(C=C3)O)N)C
MeSH Unique ID: D020881
Source: PubChem CID 104787

MeSH Record

Classification

Broader headings

Enkephalins

Related Concepts

Knowledge Graph

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Drug Class

Pharmacological Action

MeSH Record

Synonyms

17 entry terms

D-Pen2, D-Pen5-Enkephalin
D-Penicillamine (2,5)-Enkephalin
DPDPE
DPDPE(SH)2
Enkephalin, D-Penicillamine (2,5)-
Enkephalin, Pen(2,5)-
Enkephalin, Penicillamine (2,5)-
D Pen2, D Pen5 Enkephalin
D-Pen5-Enkephalin D-Pen2
Bis-Pen-Enkephalin
Bis-Penicillamine-Enkephalin
D-Pen2, L-Pen5-Enkephalin
DPLPE
Bis Pen Enkephalin
Bis Penicillamine Enkephalin
D Pen2, L Pen5 Enkephalin
L-Pen5-Enkephalin D-Pen2

MeSH Record

Aspects Covered

30 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analogs & derivatives, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.

MeSH Record

History Note

2000; use ENKEPHALIN, D-PENICILLAMINE (2,5)- (NM) 1983-1999

MeSH Record

Previous Indexing

Enkephalins (1983-1999)

MeSH Hierarchy

Tree Numbers

D12.644 w.400 w.575 w.281 w.600w
D12.776 w.631 w.650 w.575 w.281 w.600w

AMA Style

References

National Library of Medicine. D-Penicillamine (2,5)- Enkephalin. Medical Subject Headings (MeSH). 2026. Unique ID D020881. http://id.nlm.nih.gov/mesh/2026/D020881
D-Penicillamine (2,5)- Enkephalin. In: Wikipedia. https://en.wikipedia.org/wiki/DPDPE
D-Penicillamine (2,5)- Enkephalin. In: Wikidata. https://www.wikidata.org/wiki/Q27077106
D-Penicillamine (2,5)- Enkephalin. In: PubChem Compound. CID 104787. https://pubchem.ncbi.nlm.nih.gov/compound/104787