Chemicals and Drugs

DNA (Cytosine-5-)-Methyltransferase 1

A DNA (cytosine-5-)-methyltransferase that contains a central CxxC type zinc finger motif. It binds poly(ADP)-ribose and its expression is regulated by POLY (ADP-RIBOSE) POLYMERASE-1. DNMT1 methylates CpG residues, with a preference for hemimethylated DNA, and associates with DNA replication sites in S PHASE to maintain the methylation pattern in the newly synthesized strand, which is essential for EPIGENETIC PROCESSES. It also associates with CHROMATIN during G2 PHASE and MITOSIS to maintain DNA methylation independently of replication. It is responsible for maintaining methylation patterns established in development; mutations in the DNMT1 gene are associated with HEREDITARY SENSORY NEUROPATHY TYPE 1 class E.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A DNA (cytosine-5-)-methyltransferase that contains a central CxxC type zinc finger motif. It binds poly(ADP)-ribose and its expression is regulated by POLY (ADP-RIBOSE) POLYMERASE-1. DNMT1 methylates CpG residues, with a preference for hemimethylated DNA, and associates with DNA replication sites in S PHASE to maintain the methylation pattern in the newly synthesized strand, which is essential for EPIGENETIC PROCESSES. It also associates with CHROMATIN during G2 PHASE and MITOSIS to maintain DNA methylation independently of replication. It is responsible for maintaining methylation patterns established in development; mutations in the DNMT1 gene are associated with HEREDITARY SENSORY NEUROPATHY TYPE 1 class E.

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Synonyms

2 entry terms
  • DNMT1 Enzyme
  • Enzyme, DNMT1

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Aspects Covered

29 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.

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History Note

2018 (1999)

MeSH Hierarchy

Tree Numbers

  1. D08.811w.913w.555.500w.350.100.500.500
  2. D12.776w.157w.687.313
  3. D12.776w.660w.720.313

AMA Style

References

  1. National Library of Medicine. DNA (Cytosine-5-)-Methyltransferase 1. Medical Subject Headings (MeSH). 2026. Unique ID D000076123. http://id.nlm.nih.gov/mesh/2026/D000076123
  2. DNA (Cytosine-5-)-Methyltransferase 1. In: Wikidata. https://www.wikidata.org/wiki/Q5205796