Chemicals and Drugs

DNA Restriction-Modification Enzymes

Systems consisting of two enzymes, a modification methylase and a restriction endonuclease. They are closely related in their specificity and protect the DNA of a given bacterial species. The methylase adds methyl groups to adenine or cytosine residues in the same target sequence that constitutes the restriction enzyme binding site. The methylation renders the target site resistant to restriction, thereby protecting DNA against cleavage.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

Systems consisting of two enzymes, a modification methylase and a restriction endonuclease. They are closely related in their specificity and protect the DNA of a given bacterial species. The methylase adds methyl groups to adenine or cytosine residues in the same target sequence that constitutes the restriction enzyme binding site. The methylation renders the target site resistant to restriction, thereby protecting DNA against cleavage.

MeSH Record

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MeSH Record

Synonyms

17 entry terms
  • DNA Restriction Modification Enzyme
  • DNA Restriction Modification Enzymes
  • DNA Restriction-Modification Enzyme
  • Restriction Modification System
  • Restriction Modification Systems
  • Restriction-Modification System
  • Restriction-Modification Systems
  • Enzyme, DNA Restriction-Modification
  • Enzymes, DNA Restriction-Modification
  • Modification System, Restriction
  • Modification Systems, Restriction
  • Restriction-Modification Enzyme, DNA
  • Restriction-Modification Enzymes, DNA
  • System, Restriction Modification
  • System, Restriction-Modification
  • Systems, Restriction Modification
  • Systems, Restriction-Modification

MeSH Record

Aspects Covered

29 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

History Note

89

MeSH Record

Previous Indexing

  • DNA Restriction Enzymes (1975-1988)
  • Methyltransferases (1971-1988)

MeSH Hierarchy

Tree Number

  1. D08.811w.150w

AMA Style

References

  1. National Library of Medicine. DNA Restriction-Modification Enzymes. Medical Subject Headings (MeSH). 2026. Unique ID D015280. http://id.nlm.nih.gov/mesh/2026/D015280
  2. DNA Restriction-Modification Enzymes. In: Wikipedia. https://en.wikipedia.org/wiki/Restriction_modification_system
  3. DNA Restriction-Modification Enzymes. In: Wikidata. https://www.wikidata.org/wiki/Q2596062