Chemicals and Drugs

DNA Vaccines

Recombinant DNA vectors encoding antigens administered for the prevention or treatment of disease. The host cells take up the DNA, express the antigen, and present it to the immune system in a manner similar to that which would occur during natural infection. This induces humoral and cellular immune responses against the encoded antigens. The vector is called naked DNA because there is no need for complex formulations or delivery agents; the plasmid is injected in saline or other buffers.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

Recombinant DNA vectors encoding antigens administered for the prevention or treatment of disease. The host cells take up the DNA, express the antigen, and present it to the immune system in a manner similar to that which would occur during natural infection. This induces humoral and cellular immune responses against the encoded antigens. The vector is called naked DNA because there is no need for complex formulations or delivery agents; the plasmid is injected in saline or other buffers.

MeSH Record

Classification

Broader headings

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MeSH Record

Synonyms

15 entry terms
  • DNA Vaccine
  • Naked DNA Vaccine
  • Naked DNA Vaccines
  • Recombinant DNA Vaccine
  • Recombinant DNA Vaccines
  • Vaccines, DNA
  • Vaccines, Recombinant DNA
  • DNA Vaccine, Naked
  • DNA Vaccine, Recombinant
  • DNA Vaccines, Naked
  • DNA Vaccines, Recombinant
  • Vaccine, DNA
  • Vaccine, Naked DNA
  • Vaccine, Recombinant DNA
  • Vaccines, Naked DNA

MeSH Record

Aspects Covered

26 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.

MeSH Record

History Note

97

MeSH Record

Previous Indexing

  • Vaccines, Synthetic (1986-1996)

MeSH Hierarchy

Tree Numbers

  1. D12.776w.828.868w.228.250w
  2. D20.215.894w.865w.450.250w
  3. D23.050w.865w.450.250w

MeSH Record

NLM Classification

QW 805

AMA Style

References

  1. National Library of Medicine. DNA Vaccines. Medical Subject Headings (MeSH). 2026. Unique ID D019444. http://id.nlm.nih.gov/mesh/2026/D019444
  2. DNA Vaccines. In: Wikipedia. https://en.wikipedia.org/wiki/DNA_vaccine
  3. DNA Vaccines. In: Wikidata. https://www.wikidata.org/wiki/Q578537