Structured Summary
Abstract
An HIV PROTEASE INHIBITOR that is used in the treatment of AIDS and HIV INFECTIONS. Due to the emergence of ANTIVIRAL DRUG RESISTANCE when used alone, it is administered in combination with other ANTI-HIV AGENTS.
Chemical Identity
Chemical Information
- Molecular Formula
- C27H37N3O7S
- Molecular Weight
- 547.7 g/mol
- CAS Registry No.
- 206361-99-1
- IUPAC Name
- [(3aS,4R,6aR)-2,3,3a,4,5,6a-hexahydrofuro[2,3-b]furan-4-yl] N-[(2S,3R)-4-[(4-aminophenyl)sulfonyl-(2-methylpropyl)amino]-3-hydroxy-1-phenylbutan-2-yl]carbamate
- InChIKey
- CJBJHOAVZSMMDJ-HEXNFIEUSA-N
- SMILES
- CC(C)CN(C[C@H]([C@H](CC1=CC=CC=C1)NC(=O)O[C@H]2CO[C@@H]3[C@H]2CCO3)O)S(=O)(=O)C4=CC=C(C=C4)N
- MeSH Unique ID
- D000069454
- Source
- PubChem CID 213039
MeSH Record
Classification
Broader headings
Related Concepts
Knowledge Graph
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Drug Class
Pharmacological Action
MeSH Record
Synonyms
10 entry terms
- Darunavir Ethanolate
- Prezista
- TMC 114
- TMC-114
- TMC114
- UIC-94017
- UIC94017
- 114, TMC
- Ethanolate, Darunavir
- UIC 94017
MeSH Record
Aspects Covered
25 allowable subheadings
Indexed with the subheadings administration & dosage, adverse effects, agonists, analogs & derivatives, analysis, antagonists & inhibitors, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, economics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.
MeSH Record
History Note
2016 (2004)
MeSH Hierarchy
Tree Numbers
AMA Style
References
- National Library of Medicine. Darunavir. Medical Subject Headings (MeSH). 2026. Unique ID D000069454. http://id.nlm.nih.gov/mesh/2026/D000069454
- Darunavir. In: Wikipedia. https://en.wikipedia.org/wiki/Darunavir
- Darunavir. In: Wikidata. https://www.wikidata.org/wiki/Q3765251
- Darunavir. In: PubChem Compound. CID 213039. https://pubchem.ncbi.nlm.nih.gov/compound/213039