Chemicals and Drugs

Dasatinib

A pyrimidine and thiazole derived ANTINEOPLASTIC AGENT and PROTEIN KINASE INHIBITOR of BCR-ABL KINASE. It is used in the treatment of patients with CHRONIC MYELOID LEUKEMIA who are resistant or intolerant to IMATINIB.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A pyrimidine and thiazole derived ANTINEOPLASTIC AGENT and PROTEIN KINASE INHIBITOR of BCR-ABL KINASE. It is used in the treatment of patients with CHRONIC MYELOID LEUKEMIA who are resistant or intolerant to IMATINIB.

Chemical Identity

Chemical Information

Molecular Formula
C22H28ClN7O3S
Molecular Weight
506.0 g/mol
CAS Registry No.
863127-77-9
IUPAC Name
N-(2-chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyethyl)piperazin-1-yl]-2-methylpyrimidin-4-yl]amino]-1,3-thiazole-5-carboxamide;hydrate
InChIKey
XHXFZZNHDVTMLI-UHFFFAOYSA-N
SMILES
CC1=C(C(=CC=C1)Cl)NC(=O)C2=CN=C(S2)NC3=CC(=NC(=N3)C)N4CCN(CC4)CCO.O
MeSH Unique ID
D000069439
Source
PubChem CID 11540687

MeSH Record

Classification

Broader headings

Related Concepts

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Drug Class

Pharmacological Action

MeSH Record

Synonyms

7 entry terms
  • N-(2-chloro-6-methylphenyl)-2-(6-(4-(2-hydroxyethyl)piperazin-1-yl)-2-methylpyrimidin-4-ylamino)thiazole-5-carboxamide
  • (18F)-N-(2-chloro-6-methylphenyl)-2-(6-(4-(2-hydroxyethyl)piperazin-1-yl)-2-methylpyrimidin-4-ylamino)thiazole-5-carboxamide
  • BMS 354825
  • BMS-354825
  • BMS354825
  • Sprycel
  • 354825, BMS

MeSH Record

Aspects Covered

25 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analogs & derivatives, analysis, antagonists & inhibitors, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, economics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.

MeSH Record

History Note

2016 (2004)

MeSH Hierarchy

Tree Numbers

  1. D02w.886w.675.184
  2. D03w.383.129w.708.198
  3. D03w.383.742.148

AMA Style

References

  1. National Library of Medicine. Dasatinib. Medical Subject Headings (MeSH). 2026. Unique ID D000069439. http://id.nlm.nih.gov/mesh/2026/D000069439
  2. Dasatinib. In: Wikidata. https://www.wikidata.org/wiki/Q27139135
  3. Dasatinib. In: PubChem Compound. CID 11540687. https://pubchem.ncbi.nlm.nih.gov/compound/11540687