Chemicals and Drugs

Decitabine

An azacitidine derivative and antineoplastic antimetabolite. It inhibits DNA methyltransferase to re-activate silent genes, limiting METASTASIS and NEOPLASM DRUG RESISTANCE. Decitabine is used in the treatment of MYELODISPLASTIC SYNDROMES, and ACUTE MYELOID LEUKEMIA.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

An azacitidine derivative and antineoplastic antimetabolite. It inhibits DNA methyltransferase to re-activate silent genes, limiting METASTASIS and NEOPLASM DRUG RESISTANCE. Decitabine is used in the treatment of MYELODISPLASTIC SYNDROMES, and ACUTE MYELOID LEUKEMIA.

Chemical Identity

Chemical Information

Molecular Formula
C8H12N4O4
Molecular Weight
228.21 g/mol
CAS Registry No.
2353-33-5
IUPAC Name
4-amino-1-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-1,3,5-triazin-2-one
InChIKey
XAUDJQYHKZQPEU-KVQBGUIXSA-N
SMILES
C1[C@@H]([C@H](O[C@H]1N2C=NC(=NC2=O)N)CO)O
MeSH Unique ID
D000077209
Source
PubChem CID 451668

MeSH Record

Classification

Broader headings

Related Concepts

Knowledge Graph

Loading graph…

Drag nodes to rearrange; hover to trace links; click a node to open its page.

Drug Class

Pharmacological Action

MeSH Record

See Also

MeSH Record

Synonyms

18 entry terms
  • 2'-Deoxy-5-azacytidine
  • 5-Aza-2'-deoxycytidine
  • 5-AzadC
  • 5-Azadeoxycytidine
  • 5AzadC
  • AzadC Compound
  • 2' Deoxy 5 azacytidine
  • 5 Aza 2' deoxycytidine
  • 5 Azadeoxycytidine
  • Compound, AzadC
  • 5-Deoxyazacytidine
  • Dacogen
  • Decitabine Mesylate
  • NSC 127716
  • NSC-127716
  • 5 Deoxyazacytidine
  • Mesylate, Decitabine
  • NSC127716

MeSH Record

Aspects Covered

25 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analogs & derivatives, analysis, antagonists & inhibitors, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, economics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.

MeSH Record

History Note

2019 (1977)

MeSH Hierarchy

Tree Numbers

  1. D02w.145.150w.500w
  2. D03w.383.742.680.245w.217w.500w
  3. D13.570w.685.245w.217w.500w
  4. D13.570w.800w.286w.300w.500w

AMA Style

References

  1. National Library of Medicine. Decitabine. Medical Subject Headings (MeSH). 2026. Unique ID D000077209. http://id.nlm.nih.gov/mesh/2026/D000077209
  2. Decitabine. In: Wikipedia. https://en.wikipedia.org/wiki/Decitabine
  3. Decitabine. In: Wikidata. https://www.wikidata.org/wiki/Q1181878
  4. Decitabine. In: PubChem Compound. CID 451668. https://pubchem.ncbi.nlm.nih.gov/compound/451668