Chemicals and Drugs

Demeclocycline

A TETRACYCLINE analog having a 7-chloro and a 6-methyl. Because it is excreted more slowly than tetracycline, it maintains effective blood levels for longer periods of time.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A TETRACYCLINE analog having a 7-chloro and a 6-methyl. Because it is excreted more slowly than tetracycline, it maintains effective blood levels for longer periods of time.

Chemical Identity

Chemical Information

Molecular Formula
C21H21ClN2O8
Molecular Weight
464.9 g/mol
IUPAC Name
(2E,4S,4aS,5aS,6S,12aS)-2-[amino(hydroxy)methylidene]-7-chloro-4-(dimethylamino)-6,10,11,12a-tetrahydroxy-4a,5,5a,6-tetrahydro-4H-tetracene-1,3,12-trione
InChIKey
HXPZLYXFFSKHJA-GNCUHUTISA-N
SMILES
CN(C)[C@H]1[C@@H]2C[C@@H]3[C@@H](C4=C(C=CC(=C4C(=C3C(=O)[C@@]2(C(=O)/C(=C(\N)/O)/C1=O)O)O)O)Cl)O
MeSH Unique ID
D003707
Source
PubChem CID 5311063

MeSH Record

Classification

Broader headings

Related Concepts

Knowledge Graph

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Drug Class

Pharmacological Action

MeSH Record

Synonyms

11 entry terms
  • Demethylchlortetracycline
  • Declomycin
  • Demeclocycline Hydrochloride
  • Demeclocycline Monohydrochloride
  • Demeclocycline, 4-epimer
  • Demeclocycline, Calcium (1:1) Salt
  • Demeclocycline, Calcium (1:2) Salt
  • Ledermycin
  • Lédermycine
  • Hydrochloride, Demeclocycline
  • Monohydrochloride, Demeclocycline

MeSH Record

Aspects Covered

26 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analogs & derivatives, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, economics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.

MeSH Record

History Note

92; was DEMETHYLCHLORTETRACYCLINE 1963-91; DEMECLOCYCLINE was see DEMETHYLCHLORTETRACYCLINE 1975-91

MeSH Hierarchy

Tree Numbers

  1. D02w.455w.426w.559w.847w.562.900w.185w
  2. D04w.615w.562.900w.185w

AMA Style

References

  1. National Library of Medicine. Demeclocycline. Medical Subject Headings (MeSH). 2026. Unique ID D003707. http://id.nlm.nih.gov/mesh/2026/D003707
  2. Demeclocycline. In: Wikipedia. https://en.wikipedia.org/wiki/Demeclocycline
  3. Demeclocycline. In: Wikidata. https://www.wikidata.org/wiki/Q2736402
  4. Demeclocycline. In: PubChem Compound. CID 5311063. https://pubchem.ncbi.nlm.nih.gov/compound/5311063