Chemicals and Drugs

Desipramine

A tricyclic dibenzazepine compound that potentiates neurotransmission. Desipramine selectively blocks reuptake of norepinephrine from the neural synapse, and also appears to impair serotonin transport. This compound also possesses minor anticholinergic activity, through its affinity to muscarinic receptors.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A tricyclic dibenzazepine compound that potentiates neurotransmission. Desipramine selectively blocks reuptake of norepinephrine from the neural synapse, and also appears to impair serotonin transport. This compound also possesses minor anticholinergic activity, through its affinity to muscarinic receptors.

Chemical Identity

Chemical Information

Molecular Formula
C18H22N2
Molecular Weight
266.4 g/mol
CAS Registry No.
50-47-5
IUPAC Name
3-(5,6-dihydrobenzo[b][1]benzazepin-11-yl)-N-methylpropan-1-amine
InChIKey
HCYAFALTSJYZDH-UHFFFAOYSA-N
SMILES
CNCCCN1C2=CC=CC=C2CCC3=CC=CC=C31
MeSH Unique ID
D003891
Source
PubChem CID 2995

MeSH Record

Classification

Broader headings

Related Concepts

Knowledge Graph

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Drug Class

Pharmacological Action

MeSH Record

Synonyms

19 entry terms
  • Demethylimipramine
  • Desmethylimipramine
  • Apo-Desipramine
  • Desipramine Hydrochloride
  • Norpramin
  • Novo-Desipramine
  • Nu-Desipramine
  • PMS-Desipramine
  • Pertofran
  • Pertofrane
  • Pertrofran
  • Petylyl
  • Ratio-Desipramine
  • Apo Desipramine
  • Hydrochloride, Desipramine
  • Novo Desipramine
  • Nu Desipramine
  • PMS Desipramine
  • Ratio Desipramine

MeSH Record

Aspects Covered

25 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analogs & derivatives, analysis, antagonists & inhibitors, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, economics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.

MeSH Record

History Note

65(63)

MeSH Hierarchy

Tree Number

  1. D03w.633.300.240.281w

MeSH Record

NLM Classification

QV 77.5

AMA Style

References

  1. National Library of Medicine. Desipramine. Medical Subject Headings (MeSH). 2026. Unique ID D003891. http://id.nlm.nih.gov/mesh/2026/D003891
  2. Desipramine. In: Wikipedia. https://en.wikipedia.org/wiki/Desipramine
  3. Desipramine. In: Wikidata. https://www.wikidata.org/wiki/Q423288
  4. Desipramine. In: PubChem Compound. CID 2995. https://pubchem.ncbi.nlm.nih.gov/compound/2995