Structured Summary
Abstract
A deubiquitinase and tumor-suppressor protein that specifically cleaves LYSINE-63-linked polyubiquitin chains and also has endodeubiquitinase activity. It functions to regulate NF-KAPPA B and WNT SIGNALING PATHWAY activity, contributing to cell survival, proliferation, and differentiation. Mutations in the CYLD gene are associated with cases of FAMILIAL CYLINDROMATOSIS.
MeSH Record
Classification
Broader headings
Related Concepts
Knowledge Graph
Drag nodes to rearrange; hover to trace links; click a node to open its page.
MeSH Record
Synonyms
5 entry terms
- CYLD Protein
- Cylindromatosis Protein
- Deubiquitinating Enzyme Cylindromatosis
- CYLD, Deubiquitinating Enzyme
- Cylindromatosis, Deubiquitinating Enzyme
MeSH Record
Aspects Covered
29 allowable subheadings
Indexed with the subheadings administration & dosage, adverse effects, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.
MeSH Record
History Note
2018
MeSH Record
Previous Indexing
- Tumor Suppressor Proteins (2001-2017)
MeSH Hierarchy
Tree Numbers
AMA Style
References
- National Library of Medicine. Deubiquitinating Enzyme CYLD. Medical Subject Headings (MeSH). 2026. Unique ID D000074749. http://id.nlm.nih.gov/mesh/2026/D000074749
- Deubiquitinating Enzyme CYLD. In: Wikidata. https://www.wikidata.org/wiki/Q21117462