Chemicals and Drugs

Dichlororibofuranosylbenzimidazole

An RNA polymerase II transcriptional inhibitor. This compound terminates transcription prematurely by selective inhibition of RNA synthesis. It is used in research to study underlying mechanisms of cellular regulation.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

An RNA polymerase II transcriptional inhibitor. This compound terminates transcription prematurely by selective inhibition of RNA synthesis. It is used in research to study underlying mechanisms of cellular regulation.

Chemical Identity

Chemical Information

Molecular Formula
C12H12Cl2N2O4
Molecular Weight
319.14 g/mol
CAS Registry No.
53-85-0
IUPAC Name
(2R,3R,4S,5R)-2-(5,6-dichlorobenzimidazol-1-yl)-5-(hydroxymethyl)oxolane-3,4-diol
InChIKey
XHSQDZXAVJRBMX-DDHJBXDOSA-N
SMILES
C1=C2C(=CC(=C1Cl)Cl)N(C=N2)[C@H]3[C@@H]([C@@H]([C@H](O3)CO)O)O
MeSH Unique ID
D004004
Source
PubChem CID 5894

MeSH Record

Classification

Broader headings

Related Concepts

Knowledge Graph

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Drug Class

Pharmacological Action

MeSH Record

Synonyms

7 entry terms
  • 5,6-Dichloro-1-beta-D-ribofuranosyl-1-H-benzimidazol
  • 5,6-Dichloro-1-beta-ribofuranosylbenzimidazole
  • DRB
  • Dichlorobenzimidazole Riboside
  • 5,6 Dichloro 1 beta D ribofuranosyl 1 H benzimidazol
  • 5,6 Dichloro 1 beta ribofuranosylbenzimidazole
  • Riboside, Dichlorobenzimidazole

MeSH Record

Aspects Covered

25 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analogs & derivatives, analysis, antagonists & inhibitors, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, economics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.

MeSH Record

History Note

91(79); was see under RIBONUCLEOSIDES 1979-90

MeSH Record

Previous Indexing

  • Benzimidazoles (1966-1978)
  • Nucleosides (1966-1970)
  • Ribonucleosides (1971-1978)

MeSH Hierarchy

Tree Number

  1. D13.570w.800w.330w

AMA Style

References

  1. National Library of Medicine. Dichlororibofuranosylbenzimidazole. Medical Subject Headings (MeSH). 2026. Unique ID D004004. http://id.nlm.nih.gov/mesh/2026/D004004
  2. Dichlororibofuranosylbenzimidazole. In: Wikipedia. https://en.wikipedia.org/wiki/5,6-Dichloro-1-%CE%B2-D-ribofuranosylbenzimidazole
  3. Dichlororibofuranosylbenzimidazole. In: Wikidata. https://www.wikidata.org/wiki/Q4639543
  4. Dichlororibofuranosylbenzimidazole. In: PubChem Compound. CID 5894. https://pubchem.ncbi.nlm.nih.gov/compound/5894