Structured Summary
Abstract
A protein domain originally identified in DISCOIDINS. It occurs in a variety of unrelated proteins in multicellular organisms, where it recognizes different ligands with distinct biological functions. Structurally, it consists of two antiparallel beta sheets that form a jellyroll configuration stabilized by two intramolecular disulfide bonds. Sequence differences within this module determine ligand specificity; in DISCOIDIN DOMAIN RECEPTORS, it binds to FIBRILLAR COLLAGENS and NON-FIBRILLAR COLLAGENS.
MeSH Record
Classification
Broader headings
Related Concepts
Knowledge Graph
Drag nodes to rearrange; hover to trace links; click a node to open its page.
MeSH Record
Synonyms
3 entry terms
- Discoidin Domains
- Domain, Discoidin
- Domains, Discoidin
MeSH Record
Aspects Covered
5 allowable subheadings
Indexed with the subheadings drug effects, genetics, immunology, physiology, radiation effects.
MeSH Record
History Note
2017
MeSH Record
Previous Indexing
- Lectins (1998-2016)
- Protein Structure, Tertiary (1998-2016)
MeSH Hierarchy
Tree Number
AMA Style
References
- National Library of Medicine. Discoidin Domain. Medical Subject Headings (MeSH). 2026. Unique ID D000070822. http://id.nlm.nih.gov/mesh/2026/D000070822
- Discoidin Domain. In: Wikipedia. https://en.wikipedia.org/wiki/Discoidin_domain
- Discoidin Domain. In: Wikidata. https://www.wikidata.org/wiki/Q24727589