Chemicals and Drugs

Discs Large Homolog 1 Protein

A signaling adaptor protein that contains three PDZ DOMAINS; an SH3 DOMAIN; and a GUANYLATE KINASE-like C-terminal region. It has an essential role in animal development and recruits ion channels, receptors, and signaling molecules to discrete plasma membrane regions of polarized cells in the HEART ATRIA MYOCARDIUM. It functions in the assembly of ADHERENS JUNCTIONS and regulation of CELL PROLIFERATION; synaptogenesis, LYMPHOCYTE ACTIVATION; and controls expression of KV4 POTASSIUM CHANNELS to regulate excitability of CARDIAC MYOCYTES.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A signaling adaptor protein that contains three PDZ DOMAINS; an SH3 DOMAIN; and a GUANYLATE KINASE-like C-terminal region. It has an essential role in animal development and recruits ion channels, receptors, and signaling molecules to discrete plasma membrane regions of polarized cells in the HEART ATRIA MYOCARDIUM. It functions in the assembly of ADHERENS JUNCTIONS and regulation of CELL PROLIFERATION; synaptogenesis, LYMPHOCYTE ACTIVATION; and controls expression of KV4 POTASSIUM CHANNELS to regulate excitability of CARDIAC MYOCYTES.

MeSH Record

Classification

Broader headings

Related Concepts

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MeSH Record

Synonyms

2 entry terms
  • Synapse-Associated Protein 97
  • Synapse Associated Protein 97

MeSH Record

Aspects Covered

30 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

History Note

2018

MeSH Record

Previous Indexing

  • Adaptor Proteins, Signal Transducing (2006-2017)
  • Membrane Proteins (2006-2017)

MeSH Hierarchy

Tree Numbers

  1. D08.811w.913w.696w.650.450w.500
  2. D12.644w.360.024w.287
  3. D12.776w.157w.057w.023
  4. D12.776w.476.024w.325
  5. D12.776w.543w.213

AMA Style

References

  1. National Library of Medicine. Discs Large Homolog 1 Protein. Medical Subject Headings (MeSH). 2026. Unique ID D000074288. http://id.nlm.nih.gov/mesh/2026/D000074288
  2. Discs Large Homolog 1 Protein. In: Wikidata. https://www.wikidata.org/wiki/Q21113813