Chemicals and Drugs

Dishevelled Proteins

A family of proteins that are key components of the WNT SIGNALING PATHWAY, where they function downstream of FRIZZLED RECEPTORS. They contain an N-terminal dishevelled-AXIN PROTEIN (DIX) domain, which mediates oligomerization; a central PDZ DOMAIN which binds to the frizzled receptor; and a C-terminal DEP domain which facilitates binding to the CELL MEMBRANE. Dishevelled proteins have important functions in CELL DIFFERENTIATION and establishing CELL POLARITY.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A family of proteins that are key components of the WNT SIGNALING PATHWAY, where they function downstream of FRIZZLED RECEPTORS. They contain an N-terminal dishevelled-AXIN PROTEIN (DIX) domain, which mediates oligomerization; a central PDZ DOMAIN which binds to the frizzled receptor; and a C-terminal DEP domain which facilitates binding to the CELL MEMBRANE. Dishevelled proteins have important functions in CELL DIFFERENTIATION and establishing CELL POLARITY.

MeSH Record

Classification

Broader headings

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MeSH Record

Synonyms

7 entry terms
  • Dishevelled Protein
  • Dishevelled-1 Protein
  • Dishevelled-2 Protein
  • Dishevelled-3 Protein
  • Dishevelled 1 Protein
  • Dishevelled 2 Protein
  • Dishevelled 3 Protein

MeSH Record

Aspects Covered

30 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

History Note

2017 (1994)

MeSH Hierarchy

Tree Numbers

  1. D12.644w.360.024w.288w
  2. D12.776w.157w.057w.028w
  3. D12.776w.476.024w.330w

AMA Style

References

  1. National Library of Medicine. Dishevelled Proteins. Medical Subject Headings (MeSH). 2026. Unique ID D000072261. http://id.nlm.nih.gov/mesh/2026/D000072261
  2. Dishevelled Proteins. In: Wikipedia. https://en.wikipedia.org/wiki/Dishevelled
  3. Dishevelled Proteins. In: Wikidata. https://www.wikidata.org/wiki/Q5282208