Structured Summary
Abstract
A family of polypeptides purified from snake venoms, which contain the arginine-glycine-aspartic acid (RGD) sequence. The RGD tripeptide binds to integrin receptors and thus competitively inhibits normal integrin-ligand interactions. Disintegrins thus block adhesive functions and act as platelet aggregation inhibitors.
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Drug Class
Pharmacological Action
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Synonyms
1 entry terms
- Disintegrin
MeSH Record
Aspects Covered
29 allowable subheadings
Indexed with the subheadings administration & dosage, adverse effects, agonists, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.
MeSH Record
Indexing Annotation
polypeptides from snake venom; platelet aggregation inhib
MeSH Record
History Note
97; was DISINTEGRINS (NM) 1992-96
MeSH Record
Previous Indexing
- Peptides (1992-1996)
- Venoms (1992-1994)
MeSH Hierarchy
Tree Number
AMA Style
References
- National Library of Medicine. Disintegrins. Medical Subject Headings (MeSH). 2026. Unique ID D019483. http://id.nlm.nih.gov/mesh/2026/D019483
- Disintegrins. In: Wikidata. https://www.wikidata.org/wiki/Q41797548