Chemicals and Drugs

Disulfiram

A carbamate derivative used as an alcohol deterrent. It is a relatively nontoxic substance when administered alone, but markedly alters the intermediary metabolism of alcohol. When alcohol is ingested after administration of disulfiram, blood acetaldehyde concentrations are increased, followed by flushing, systemic vasodilation, respiratory difficulties, nausea, hypotension, and other symptoms (acetaldehyde syndrome). It acts by inhibiting aldehyde dehydrogenase.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A carbamate derivative used as an alcohol deterrent. It is a relatively nontoxic substance when administered alone, but markedly alters the intermediary metabolism of alcohol. When alcohol is ingested after administration of disulfiram, blood acetaldehyde concentrations are increased, followed by flushing, systemic vasodilation, respiratory difficulties, nausea, hypotension, and other symptoms (acetaldehyde syndrome). It acts by inhibiting aldehyde dehydrogenase.

Chemical Identity

Chemical Information

Molecular Formula
C10H20N2S4
Molecular Weight
296.5 g/mol
CAS Registry No.
97-77-8
IUPAC Name
diethylcarbamothioylsulfanyl N,N-diethylcarbamodithioate
InChIKey
AUZONCFQVSMFAP-UHFFFAOYSA-N
SMILES
CCN(CC)C(=S)SSC(=S)N(CC)CC
MeSH Unique ID
D004221
Source
PubChem CID 3117

MeSH Record

Classification

Broader headings

Related Concepts

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Drug Class

Pharmacological Action

MeSH Record

Synonyms

11 entry terms
  • Bis(diethylthiocarbamoyl) Disulfide
  • Tetraethylthioperoxydicarbonic Diamide, ((H2N)C(S))2S2
  • Tetraethylthiuram Disulfide
  • Disulfide, Tetraethylthiuram
  • Alcophobin
  • Antabus
  • Antabuse
  • Anticol
  • Dicupral
  • Esperal
  • Teturam

MeSH Record

Aspects Covered

25 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analogs & derivatives, analysis, antagonists & inhibitors, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, economics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.

MeSH Record

History Note

1966

MeSH Hierarchy

Tree Numbers

  1. D02w.241w.081.251w.869w.220.250w
  2. D02w.886w.520w.150w.175w
  3. D02w.886w.706w.200.200w

AMA Style

References

  1. National Library of Medicine. Disulfiram. Medical Subject Headings (MeSH). 2026. Unique ID D004221. http://id.nlm.nih.gov/mesh/2026/D004221
  2. Disulfiram. In: Wikipedia. https://en.wikipedia.org/wiki/Disulfiram
  3. Disulfiram. In: Wikidata. https://www.wikidata.org/wiki/Q409665
  4. Disulfiram. In: PubChem Compound. CID 3117. https://pubchem.ncbi.nlm.nih.gov/compound/3117