Chemicals and Drugs

Docetaxel

A semisynthetic analog of PACLITAXEL used in the treatment of locally advanced or metastatic BREAST NEOPLASMS and NON-SMALL CELL LUNG CANCER.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A semisynthetic analog of PACLITAXEL used in the treatment of locally advanced or metastatic BREAST NEOPLASMS and NON-SMALL CELL LUNG CANCER.

Chemical Identity

Chemical Information

Molecular Formula
C43H53NO14
Molecular Weight
807.9 g/mol
CAS Registry No.
114977-28-5
IUPAC Name
[(1S,2S,3R,4S,7R,9S,10S,12R,15S)-4-acetyloxy-1,9,12-trihydroxy-15-[(2R,3S)-2-hydroxy-3-[(2-methylpropan-2-yl)oxycarbonylamino]-3-phenylpropanoyl]oxy-10,14,17,17-tetramethyl-11-oxo-6-oxatetracyclo[11.3.1.03,10.04,7]heptadec-13-en-2-yl] benzoate
InChIKey
ZDZOTLJHXYCWBA-VCVYQWHSSA-N
SMILES
CC1=C2[C@H](C(=O)[C@@]3([C@H](C[C@@H]4[C@]([C@H]3[C@@H]([C@@](C2(C)C)(C[C@@H]1OC(=O)[C@@H]([C@H](C5=CC=CC=C5)NC(=O)OC(C)(C)C)O)O)OC(=O)C6=CC=CC=C6)(CO4)OC(=O)C)O)C)O
MeSH Unique ID
D000077143
Source
PubChem CID 148124

MeSH Record

Classification

Broader headings

Related Concepts

Knowledge Graph

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Drug Class

Pharmacological Action

MeSH Record

Synonyms

12 entry terms
  • Docetaxel Hydrate
  • Docetaxel Trihydrate
  • Docetaxol
  • Docetaxel Anhydrous
  • N-Debenzoyl-N-tert-butoxycarbonyl-10-deacetyltaxol
  • NSC 628503
  • RP 56976
  • RP-56976
  • Taxoltere Metro
  • Taxotere
  • N Debenzoyl N tert butoxycarbonyl 10 deacetyltaxol
  • RP56976

MeSH Record

Aspects Covered

25 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analogs & derivatives, analysis, antagonists & inhibitors, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, economics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.

MeSH Record

History Note

2019 (1991)

MeSH Hierarchy

Tree Numbers

  1. D02w.455w.426w.392.368w.242w.888w.389w
  2. D02w.455w.849w.291w.850w.389w

AMA Style

References

  1. National Library of Medicine. Docetaxel. Medical Subject Headings (MeSH). 2026. Unique ID D000077143. http://id.nlm.nih.gov/mesh/2026/D000077143
  2. Docetaxel. In: Wikipedia. https://en.wikipedia.org/wiki/Docetaxel
  3. Docetaxel. In: Wikidata. https://www.wikidata.org/wiki/Q420436
  4. Docetaxel. In: PubChem Compound. CID 148124. https://pubchem.ncbi.nlm.nih.gov/compound/148124