Chemicals and Drugs

Dopamine Antagonists

Drugs that bind to but do not activate DOPAMINE RECEPTORS, thereby blocking the actions of dopamine or exogenous agonists. Many drugs used in the treatment of psychotic disorders (ANTIPSYCHOTIC AGENTS) are dopamine antagonists, although their therapeutic effects may be due to long-term adjustments of the brain rather than to the acute effects of blocking dopamine receptors. Dopamine antagonists have been used for several other clinical purposes including as ANTIEMETICS, in the treatment of Tourette syndrome, and for hiccup. Dopamine receptor blockade is associated with NEUROLEPTIC MALIGNANT SYNDROME.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

Drugs that bind to but do not activate DOPAMINE RECEPTORS, thereby blocking the actions of dopamine or exogenous agonists. Many drugs used in the treatment of psychotic disorders (ANTIPSYCHOTIC AGENTS) are dopamine antagonists, although their therapeutic effects may be due to long-term adjustments of the brain rather than to the acute effects of blocking dopamine receptors. Dopamine antagonists have been used for several other clinical purposes including as ANTIEMETICS, in the treatment of Tourette syndrome, and for hiccup. Dopamine receptor blockade is associated with NEUROLEPTIC MALIGNANT SYNDROME.

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Synonyms

17 entry terms
  • Antagonists, Dopamine
  • Antagonists, Dopamine Receptor
  • Antagonists, Dopaminergic
  • Dopamine Antagonist
  • Dopamine Blocker
  • Dopamine Blockers
  • Dopamine Receptor Antagonist
  • Dopamine Receptor Antagonists
  • Dopaminergic Antagonist
  • Dopaminergic Antagonists
  • Antagonist, Dopamine
  • Antagonist, Dopamine Receptor
  • Antagonist, Dopaminergic
  • Blocker, Dopamine
  • Blockers, Dopamine
  • Receptor Antagonist, Dopamine
  • Receptor Antagonists, Dopamine

MeSH Record

Aspects Covered

22 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, analysis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, economics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.

MeSH Record

History Note

95

MeSH Record

Previous Indexing

  • Dopamine/antagonists & inhibitors (1966-1994)

MeSH Hierarchy

Tree Numbers

  1. D27.505.519w.625.150w.175w
  2. D27.505.696.577.150w.175w

AMA Style

References

  1. National Library of Medicine. Dopamine Antagonists. Medical Subject Headings (MeSH). 2026. Unique ID D018492. http://id.nlm.nih.gov/mesh/2026/D018492
  2. Dopamine Antagonists. In: Wikipedia. https://en.wikipedia.org/wiki/Dopamine_antagonist
  3. Dopamine Antagonists. In: Wikidata. https://www.wikidata.org/wiki/Q3271533