Phenomena and Processes

Down-Regulation

A negative regulatory effect on physiological processes at the molecular, cellular, or systemic level. At the molecular level, the major regulatory sites include membrane receptors, genes (GENE EXPRESSION REGULATION), mRNAs (RNA, MESSENGER), and proteins.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A negative regulatory effect on physiological processes at the molecular, cellular, or systemic level. At the molecular level, the major regulatory sites include membrane receptors, genes (GENE EXPRESSION REGULATION), mRNAs (RNA, MESSENGER), and proteins.

MeSH Record

Classification

Broader headings

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See Also

MeSH Record

Synonyms

5 entry terms
  • Down-Regulation (Physiology)
  • Downregulation
  • Down Regulation
  • Receptor Down-Regulation
  • Down-Regulation, Receptor

MeSH Record

Aspects Covered

5 allowable subheadings

Indexed with the subheadings drug effects, genetics, immunology, physiology, radiation effects.

MeSH Record

History Note

2002 (1990)

MeSH Hierarchy

Tree Numbers

  1. G02.111.240
  2. G05.308w.200
  3. G07.690.773.937

AMA Style

References

  1. National Library of Medicine. Down-Regulation. Medical Subject Headings (MeSH). 2026. Unique ID D015536. http://id.nlm.nih.gov/mesh/2026/D015536
  2. Down-Regulation. In: Wikidata. https://www.wikidata.org/wiki/Q22260640