Chemicals and Drugs

Droperidol

A butyrophenone with general properties similar to those of HALOPERIDOL. It is used in conjunction with an opioid analgesic such as FENTANYL to maintain the patient in a calm state of neuroleptanalgesia with indifference to surroundings but still able to cooperate with the surgeon. It is also used as a premedicant, as an antiemetic, and for the control of agitation in acute psychoses. (From Martindale, The Extra Pharmacopoeia, 29th ed, p593)

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A butyrophenone with general properties similar to those of HALOPERIDOL. It is used in conjunction with an opioid analgesic such as FENTANYL to maintain the patient in a calm state of neuroleptanalgesia with indifference to surroundings but still able to cooperate with the surgeon. It is also used as a premedicant, as an antiemetic, and for the control of agitation in acute psychoses. (From Martindale, The Extra Pharmacopoeia, 29th ed, p593)

Chemical Identity

Chemical Information

Molecular Formula
C22H22FN3O2
Molecular Weight
379.4 g/mol
CAS Registry No.
548-73-2
IUPAC Name
3-[1-[4-(4-fluorophenyl)-4-oxobutyl]-3,6-dihydro-2H-pyridin-4-yl]-1H-benzimidazol-2-one
InChIKey
RMEDXOLNCUSCGS-UHFFFAOYSA-N
SMILES
C1CN(CC=C1N2C3=CC=CC=C3NC2=O)CCCC(=O)C4=CC=C(C=C4)F
MeSH Unique ID
D004329
Source
PubChem CID 3168

MeSH Record

Classification

Broader headings

Related Concepts

Knowledge Graph

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Drug Class

Pharmacological Action

MeSH Record

Synonyms

4 entry terms
  • Dehidrobenzperidol
  • Dehydrobenzperidol
  • Droleptan
  • Inapsine

MeSH Record

Aspects Covered

25 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analogs & derivatives, analysis, antagonists & inhibitors, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, economics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.

MeSH Record

History Note

74(73)

MeSH Hierarchy

Tree Numbers

  1. D02w.522w.352.343w
  2. D03w.633.100.103.393w

AMA Style

References

  1. National Library of Medicine. Droperidol. Medical Subject Headings (MeSH). 2026. Unique ID D004329. http://id.nlm.nih.gov/mesh/2026/D004329
  2. Droperidol. In: Wikipedia. https://en.wikipedia.org/wiki/Droperidol
  3. Droperidol. In: Wikidata. https://www.wikidata.org/wiki/Q174259
  4. Droperidol. In: PubChem Compound. CID 3168. https://pubchem.ncbi.nlm.nih.gov/compound/3168