Chemicals and Drugs

Dysbindin

A dystrophin-associated protein and component of the Biogenesis of Lysosomal Organelles Complex-1 (BLOC-1 complex) which is essential for the formation of LYSOSOME - derived organelles such as platelet dense granules and MELANOSOMES. DTNBP1 is expressed primarily in the brain and neurons, where it functions with ADAPTOR PROTEIN COMPLEX 3 to transport membrane proteins to NEURITES and nerve terminals. It also regulates the release of neurotransmitters, transport of synaptic vesicles, and localization of DOPAMINE D2 RECEPTORS. Mutations in the DTNBP1 gene are associated with Type 7 HERMANSKY-PUDLAK SYNDROME and SCHIZOPHRENIA.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A dystrophin-associated protein and component of the Biogenesis of Lysosomal Organelles Complex-1 (BLOC-1 complex) which is essential for the formation of LYSOSOME - derived organelles such as platelet dense granules and MELANOSOMES. DTNBP1 is expressed primarily in the brain and neurons, where it functions with ADAPTOR PROTEIN COMPLEX 3 to transport membrane proteins to NEURITES and nerve terminals. It also regulates the release of neurotransmitters, transport of synaptic vesicles, and localization of DOPAMINE D2 RECEPTORS. Mutations in the DTNBP1 gene are associated with Type 7 HERMANSKY-PUDLAK SYNDROME and SCHIZOPHRENIA.

MeSH Record

Classification

Broader headings

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MeSH Record

Synonyms

6 entry terms
  • DTNBP1 Protein
  • Dysbindin-1
  • Dystrobrevin Binding Protein 1
  • Hermansky-Pudlak Syndrome 7 Protein
  • Dysbindin 1
  • Hermansky Pudlak Syndrome 7 Protein

MeSH Record

Aspects Covered

30 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

History Note

2018

MeSH Record

Previous Indexing

  • Dystrophin-Associated Proteins (2001-2017)

MeSH Hierarchy

Tree Numbers

  1. D12.776w.210.500.410w.250
  2. D12.776w.220.362w.125
  3. D12.776w.543w.268w.250
  4. D12.776w.543w.990w.447
  5. D12.776w.631w.262

AMA Style

References

  1. National Library of Medicine. Dysbindin. Medical Subject Headings (MeSH). 2026. Unique ID D000074765. http://id.nlm.nih.gov/mesh/2026/D000074765
  2. Dysbindin. In: Wikidata. https://www.wikidata.org/wiki/Q24771310