Structured Summary
Abstract
A membrane protein that contains multiple C2 DOMAINS. It is highly expressed in skeletal muscle and functions as a calcium ion sensor in SYNAPTIC VESICLE-PLASMA MEMBRANE fusion, as well as in SARCOLEMMA repair following mechanical stress. Mutations in the dysferlin (DYSF) gene are associated with several hereditary MUSCULAR DYSTROPHIES.
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Classification
Broader headings
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Synonyms
2 entry terms
- Fer-1-like Protein 1
- Fer 1 like Protein 1
MeSH Record
Aspects Covered
30 allowable subheadings
Indexed with the subheadings administration & dosage, adverse effects, agonists, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.
MeSH Record
History Note
2018
MeSH Record
Previous Indexing
- Membrane Proteins (1998-2017)
- Muscle Proteins (1998-2017)
MeSH Hierarchy
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AMA Style
References
- National Library of Medicine. Dysferlin. Medical Subject Headings (MeSH). 2026. Unique ID D000073939. http://id.nlm.nih.gov/mesh/2026/D000073939
- Dysferlin. In: Wikidata. https://www.wikidata.org/wiki/Q29956379