Phenomena and Processes

ETS Motif

A helix-turn-helix motif characterized by three alpha-helices and four-stranded beta-sheets arranged in the order alpha1-beta1-beta2-alpha2-alpha3-beta3-beta4. The third alpha-helix contacts the major groove of DNA. The ETS motif and the flanking amino acid sequences of Ets proteins influence the binding affinity, and the alteration of a single amino acid in the Ets domain can change its DNA binding specificity.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A helix-turn-helix motif characterized by three alpha-helices and four-stranded beta-sheets arranged in the order alpha1-beta1-beta2-alpha2-alpha3-beta3-beta4. The third alpha-helix contacts the major groove of DNA. The ETS motif and the flanking amino acid sequences of Ets proteins influence the binding affinity, and the alteration of a single amino acid in the Ets domain can change its DNA binding specificity.

MeSH Record

Classification

Broader headings

Related Concepts

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See Also

MeSH Record

Synonyms

5 entry terms
  • ETS Domain
  • Helix-Turn-Helix, ETS-Type Domain Containing
  • ETS Domains
  • ETS Motifs
  • Helix Turn Helix, ETS Type Domain Containing

MeSH Record

Aspects Covered

5 allowable subheadings

Indexed with the subheadings drug effects, genetics, immunology, physiology, radiation effects.

MeSH Record

History Note

2017

MeSH Record

Previous Indexing

  • Amino Acid Sequence (1990-2016)
  • Proto-Oncogene Proteins (1990-2016)
  • Transcription Factors (1990-2016)

MeSH Hierarchy

Tree Number

  1. G02.111.570.820w.709.275.500.360.360w.500

AMA Style

References

  1. National Library of Medicine. ETS Motif. Medical Subject Headings (MeSH). 2026. Unique ID D000071419. http://id.nlm.nih.gov/mesh/2026/D000071419
  2. ETS Motif. In: Wikidata. https://www.wikidata.org/wiki/Q24782417