Structured Summary
Abstract
A cytotoxic polypeptide quinoxaline antibiotic isolated from Streptomyces echinatus that binds to DNA and inhibits RNA synthesis.
Chemical Identity
Chemical Information
- Molecular Formula
- C51H64N12O12S2
- Molecular Weight
- 1101.3 g/mol
- CAS Registry No.
- 1403-88-9
- IUPAC Name
- N-[2,4,12,15,17,25-hexamethyl-27-methylsulfanyl-3,6,10,13,16,19,23,26-octaoxo-11,24-di(propan-2-yl)-20-(quinoxaline-2-carbonylamino)-9,22-dioxa-28-thia-2,5,12,15,18,25-hexazabicyclo[12.12.3]nonacosan-7-yl]quinoxaline-2-carboxamide
- InChIKey
- AUJXLBOHYWTPFV-UHFFFAOYSA-N
- SMILES
- CC1C(=O)N(C2CSC(C(C(=O)N(C(C(=O)OCC(C(=O)N1)NC(=O)C3=NC4=CC=CC=C4N=C3)C(C)C)C)N(C(=O)C(NC(=O)C(COC(=O)C(N(C2=O)C)C(C)C)NC(=O)C5=NC6=CC=CC=C6N=C5)C)C)SC)C
- MeSH Unique ID
- D004448
- Source
- PubChem CID 3197
MeSH Record
Classification
Broader headings
Related Concepts
Knowledge Graph
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Drug Class
Pharmacological Action
MeSH Record
Synonyms
4 entry terms
- Quinomycin A
- NSC-526417
- NSC 526417
- NSC526417
MeSH Record
Aspects Covered
26 allowable subheadings
Indexed with the subheadings administration & dosage, adverse effects, agonists, analogs & derivatives, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, economics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.
MeSH Record
History Note
91(76); was see under QUINOXALINES 1976-90
MeSH Record
Previous Indexing
- Antibiotics (1968-1975)
- Peptides, Cyclic (1975)
- Quinoxalines (1972-1975)
MeSH Hierarchy
Tree Numbers
AMA Style
References
- National Library of Medicine. Echinomycin. Medical Subject Headings (MeSH). 2026. Unique ID D004448. http://id.nlm.nih.gov/mesh/2026/D004448
- Echinomycin. In: Wikipedia. https://en.wikipedia.org/wiki/Echinomycin
- Echinomycin. In: Wikidata. https://www.wikidata.org/wiki/Q5332566
- Echinomycin. In: PubChem Compound. CID 3197. https://pubchem.ncbi.nlm.nih.gov/compound/3197